Actively Recruiting
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Led by Janssen Research & Development, LLC · Updated on 2026-05-08
700
Participants Needed
175
Research Sites
729 weeks
Total Duration
On this page
Sponsors
J
Janssen Research & Development, LLC
Lead Sponsor
P
Pharmacyclics LLC.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to collect long-term safety and efficacy data for participants treated with ibrutinib and to provide ongoing access to ibrutinib for participants who are currently enrolled in ibrutinib studies that have been completed according to the parent protocol, are actively receiving treatment with ibrutinib, and who continue to benefit from ibrutinib treatment.
CONDITIONS
Official Title
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants currently enrolled in a completed ibrutinib clinical study with at least 6 months of ibrutinib treatment, actively receiving single-agent ibrutinib; or participants from a randomized ibrutinib study who crossed over to ibrutinib treatment (less than 6 months prior treatment allowed with more safety checks); or participants in study PCI-32765LYM1002 actively receiving ibrutinib alone or with nivolumab
- Investigator assesses benefits of continued ibrutinib therapy outweigh risks
- Agreement to use effective contraception as defined in the protocol
- Negative pregnancy test (blood or urine) at screening
You will not qualify if you...
- Need for anticoagulation treatment with warfarin or equivalent vitamin K antagonists
- Need for treatment with strong cytochrome P450 (CYP)3A4/5 inhibitors unless approved by the sponsor
- Any condition or situation that the investigator believes poses significant risk, could affect study results, or interfere with participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 175 locations
1
City of Hope Cancer Center
Duarte, California, United States, 91010
Completed
2
University of California San Diego Medical Center
La Jolla, California, United States, 92093
Completed
3
University of California Los Angeles
Los Angeles, California, United States, 90095
Completed
4
St. Joseph Hospital Center for Cancer Prevention and Treatment
Orange, California, United States, 92868
Actively Recruiting
5
Stanford University Medical Center
Stanford, California, United States, 94305
Completed
6
Stanford University
Stanford, California, United States, 94305
Completed
7
Norwalk Medical Group
Norwalk, Connecticut, United States, 06850
Completed
8
Northwest Georgia Oncology Centers PC
Marietta, Georgia, United States, 30060
Completed
9
Northwestern University Hospital
Chicago, Illinois, United States, 60611
Completed
10
Indiana University
Goshen, Indiana, United States, 46526
Completed
11
Kansas University Medical Center
Westwood, Kansas, United States, 66205
Completed
12
Louisville Oncology Suburban - Norton Cancer Institute
Louisville, Kentucky, United States, 40207
Completed
13
Dana Farber Cancer Center
Boston, Massachusetts, United States, 02215
Completed
14
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109
Completed
15
Battle Creek Health Systm
Battle Creek, Michigan, United States, 49016
Completed
16
Karmanos Cancer Institute - Wayne State University
Detroit, Michigan, United States, 48201
Completed
17
Washington University
St Louis, Missouri, United States, 63110
Completed
18
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Completed
19
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Completed
20
Weill Medical College of Cornell University
New York, New York, United States, 10021
Completed
21
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065
Completed
22
Southeastern Medical Oncology Center
Goldsboro, North Carolina, United States, 27534
Completed
23
The Ohio State University- James Cancer Hospital
Columbus, Ohio, United States, 43210
Actively Recruiting
24
Willamette Valley Cancer Center
Eugene, Oregon, United States, 97401
Actively Recruiting
25
Kaiser Permanente
Portland, Oregon, United States, 97227
Completed
26
University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, United States, 19104
Completed
27
Avera Medical Group
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
28
MD Anderson Cancer Center - University of Texas
Houston, Texas, United States, 77030
Completed
29
University of Virginia
Charlottesville, Virginia, United States, 22908
Completed
30
University of Washington
Seattle, Washington, United States, 98109
Completed
31
West Virginia University
Morgantown, West Virginia, United States, 26506
Completed
32
University of Wisconsin Carbone Cancer Center - Wisconsin Institute for Medical Research
Madison, Wisconsin, United States, 53705
Completed
33
CEMIC Saavedra
Ciudad Autonoma Buenos Aires, Argentina, C1431
Active, Not Recruiting
34
Fundaleu
Ciudad de Buenos Aires, Argentina, C1114AAP
Completed
35
Royal Adelaide Hospital
Adelaide, Australia, 5000
Active, Not Recruiting
36
John Fawkner Cancer Trial Centre
Coburg, Australia, 3058
Completed
37
Concord Hospital
Concord, Australia, 2139
Completed
38
Austin Health
Heidelberg, Australia, 3084
Completed
39
Peter MacCallum Cancer Centre
Melbourne, Australia, 3000
Completed
40
Royal Perth Hospital
Perth, Australia, 6847
Completed
41
Alfred Hospital
Prahran, Australia, 3181
Completed
42
Adventist Health Care Limited trading as San Clinical Trials Unit
Wahroonga, Australia, 2076
Actively Recruiting
43
UZA
Antwerp, Belgium, 2650
Completed
44
A.Z. Sint Jan
Bruges, Belgium, 8000
Completed
45
UCL - Saint Luc
Brussels, Belgium, 1200
Completed
46
UZ Gent - departement oncologie
Ghent, Belgium, 9000
Completed
47
UZ Leuven Gasthuisberg
Leuven, Belgium, 3000
Completed
48
UCL Mont-Godinne
Yvoir, Belgium, 5530
Actively Recruiting
49
Ministerio da Saude Instituto Nacional do Cancer
Rio de Janeiro, Brazil, 20231 050
Completed
50
Santa Casa da Misericórdia da Bahia - Hospital Santa Isabel
Salvador, Brazil, 40050 410
Completed
51
Instituto de Ensino e Pesquisa São Lucas
São Paulo, Brazil, 01236-030
Completed
52
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Completed
53
Peking University People's Hospital
Beijing, China, 100044
Actively Recruiting
54
Peking University Third Hospital
Beijing, China, 100083
Actively Recruiting
55
Peking University First Hospital
Beijing, China
Completed
56
West China Hospital Sichuan University
Chengdu, China, 610041
Actively Recruiting
57
Fujian Medical University
Fuzhou, China, 350001
Completed
58
Sun Yat-sen University Cancer Hospital
Guangzhou, China, 510060
Completed
59
Zhejiang University First Hospital
Hangzhou, China, 310003
Actively Recruiting
60
Ruijin Hospital
Shanghai, China, 200025
Completed
61
Tangdu hospital the Fourth Military Medical
Shanxi, China, 710038
Actively Recruiting
62
The First Affliated Hospital of Soochow University
Suzhou, China
Actively Recruiting
63
The Institute of Hematological disease
Tianjin, China, 300070
Completed
64
Wuhan Union Hospital
Wuhan, China, 430023
Completed
65
Fundacion Santa Fe
Bogotá, Colombia
Completed
66
Fundacion Oftalmologica de Santander - FOSCAL
Floridablanca, Colombia, 681002
Completed
67
Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika
Brno, Czechia, 625 00
Completed
68
Fakultni nemocnice Kralovske Vinohrady - Interni hematologicka klinika
Prague, Czechia, 100 34
Completed
69
Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie
Prague, Czechia, 128 08
Completed
70
Hopital Henri Mondor
Créteil, France, 94010
Completed
71
Hôpital E. Muller
Mulhouse, France, 68100
Completed
72
HOPITAL SAINT LOUIS - Hematology / Oncology
Paris, France, 75010
Completed
73
Hopital Necker Enfants Malades
Paris, France, 75743
Completed
74
Hopital Haut Leveque Service Maladie Du Sang
Pessac, France, 33604
Completed
75
CH LYON SUD - Hematology
Pierre-Bénite, France, 69310
Completed
76
CHU de Tours
Tours, France, 37044
Active, Not Recruiting
77
Vivantes Klinikum Spandau-Klinik f. Innere Medizin Hämatologie/Onkologie/Gastroenterologie - Germany
Berlin, Germany, 13589
Completed
78
Universitätsklinikum Carl Gustav Carus; Med. Klinik und Poliklinik I - Hämatologische Ambulanz, Haus
Dresden, Germany, 01307
Completed
79
Universitätsklinikum Essen; Klinik f. Hämatologie- Germany
Essen, Germany, 45122
Completed
80
Justus-Liebig-Universitaet - Medizinische Klinik IV, Haematologie
Giessen, Germany, 35592
Actively Recruiting
81
Universitätsklinikum Heidelberg Med. Klinik IV
Heidelberg, Germany, 69120
Completed
82
Universitätsklinikum des Saarlandes
Homburg/Saar, Germany, 66424
Completed
83
Gemeinschaftspraxis Dres. Uhle/Müller/Kröning/Jentsch-Ullrich - Germany
Magdeburg, Germany, 39104
Completed
84
OnkoNet Marburg GmbH
Marburg, Germany, 35037
Completed
85
Universitätsklinikum für Innere Med. III_Hämatologie, Onkologie...- Germany
Ulm, Germany, 89081
Completed
86
Laiko General Hospital - 1st department of Internal Medicine
Athens, Greece, 115 27
Completed
87
G Papanikolaou Hospital of Thessaloniki
Thessalonikis, Greece, 570 10
Completed
88
Semmelweis Egyetem, I. Belgyogyaszati Klinika
Budapest, Hungary, 1083
Completed
89
Szegedi Tudomanyegyetem II. Belgyogyaszati Klinika
Szeged, Hungary, 6725
Completed
90
St James's Hospital
Dublin, Ireland, 00000
Completed
91
Haemek Medical Center
Afula, Israel
Completed
92
Hillel Yaffe Medical Center - Oncology
Hadera, Israel, 38100
Actively Recruiting
93
Rambam Health Care Campus
Haifa, Israel, 31096
Completed
94
Rabin Medical Center Beilinson Campus
Petah Tikva, Israel, 4941492
Completed
95
Sheba Medical Center
Ramat Gan, Israel, 52621
Completed
96
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel, 64239
Actively Recruiting
97
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Completed
98
DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA''
Roma, Italy, 00161
Completed
99
A.O.Citta della Salute e della Scienza di Torino
Torino, Italy, 10126
Completed
100
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyō City, Japan, 113 8677
Completed
101
Hiroshima University Hospital
Hiroshima, Japan, 734 8551
Actively Recruiting
102
Oaxaca Site Management Organization S.C.
Oaxaca City, Mexico, 68000
Completed
103
VU medisch centrum - Afd.Interne - INT
Amsterdam, Netherlands, 1081 HV
Completed
104
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
Brzozów, Poland, 36-200
Completed
105
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich
Chorzów, Poland, 41-500
Completed
106
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80 952
Actively Recruiting
107
Pratia MCM Krakow
Krakow, Poland, 30 510
Actively Recruiting
108
Oddzial Hematologii
Opole, Poland, 45-061
Completed
109
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka
Słupsk, Poland, 76-200
Completed
110
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
Warsaw, Poland, 02-781
Actively Recruiting
111
Katedra I Klinika Hematologii Nowotworow Krwi I Transplantacji Szpiku
Wroclaw, Poland, 50 367
Actively Recruiting
112
Instituto Portugues de Oncologia Lisboa
Lisbon, Portugal, 1600
Completed
113
Hospital De Santa Maria
Lisbon, Portugal, 1649-035
Completed
114
Instituto Portugues de Oncologia Porto
Porto, Portugal, 4200072
Active, Not Recruiting
115
Auxilio Mutuo Cancer Center
San Juan, Puerto Rico, 00919
Actively Recruiting
116
Arkhangelsk Regional Clinical Hospital
Arkhangelsk, Russia, 163045
Completed
117
Chelyabinsk Regiona Onc. Center
Chelyabinsk, Russia, 454087
Completed
118
Emergency Hospital of Dzerzhinsk
Dzerzhinsk, Russia, 606019
Completed
119
Cancer Research Center
Moscow, Russia, 115478
Completed
120
S.P. Botkin Moscow City Clinical Hospital
Moscow, Russia, 125284
Actively Recruiting
121
Regional Clinical Hospital n.a.Semashko
Nizhny Novgorod, Russia, 603126
Actively Recruiting
122
Medical Scientific Radiology - Center
Obninsk, Russia, 249020
Completed
123
Perm Medical Sanitary Unit#1
Perm, Russia, 614078
Completed
124
Republican Hospital named by V.A.Baranova
Petrozavodsk, Russia, 185019
Actively Recruiting
125
Rostov Research Institute of Oncology
Rostov-on-Don, Russia, 344037
Completed
126
Ryazan Regional Clinical Hospital
Ryazan, Russia, 390039
Actively Recruiting
127
Clinical Research Institute of Hematology and Transfusiology
Saint Petersburg, Russia, 193024
Actively Recruiting
128
Federal Center of Heart, Blood and Endocrinology
Saint Petersburg, Russia, 197341
Actively Recruiting
129
City Clinical Oncology Dispensary
Saint Petersburg, Russia, 198255
Completed
130
Leningrad region clinical hospital
Saint, Russia, 194291
Completed
131
Samara Region Clinical Hospital
Samara, Russia, 443095
Completed
132
Oncological dispensary #2
Sochi, Russia, 354057
Actively Recruiting
133
Oncology Dispensary of Komi Republic
Syktyvkar, Russia, 167904
Completed
134
National Cancer Center
Goyang-si, South Korea, 10408
Completed
135
The Catholic University of Korea Seoul St Mary s Hospital
Seoul, South Korea, 06591
Actively Recruiting
136
Hospital Vall d'Hebron
Barcelona, Spain, 00000
Actively Recruiting
137
Inst. Cat. Doncologia-H Duran I Reynals
L'Hospitalet de Llobregat, Spain, 08907
Completed
138
Hosp. Univ. de La Princesa
Madrid, Spain, 28006
Completed
139
Hosp. Gral. Univ. Gregorio Maranon
Madrid, Spain, 28007
Completed
140
Hosp. Univ. Infanta Leonor
Madrid, Spain, 28031
Completed
141
Fundacion Jimenez Diaz
Madrid, Spain, 28040
Completed
142
Clinica Universitaria de Navarra
Pamplona, Spain, 31008
Completed
143
Hospital Clinico Universitario Salamanca
Salamanca, Spain, 37007
Actively Recruiting
144
Sahlgrenska University hospital, Hematology Dept
Gothenburg, Sweden, SE-413 45
Completed
145
Skanes universitetssjukhus
Lund, Sweden, 22185
Completed
146
Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm
Stockholm, Sweden, 171 76
Completed
147
Changhua Cristian Hospital
Changhua County, Taiwan, 500
Completed
148
Ankara University
Ankara, Turkey (Türkiye), 6590
Completed
149
American Hospital
Istanbul, Turkey (Türkiye), 34365
Completed
150
Istanbul University
Istanbul, Turkey (Türkiye), 34390
Completed
151
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, Turkey (Türkiye), 35340
Completed
152
Erciyes University
Kayseri, Turkey (Türkiye), 38039
Completed
153
Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council'
Cherkasy, Ukraine, 18009
Active, Not Recruiting
154
Dnepropetrovsk City Clinical Hospital #4, Regional Hematology Center
Dnipro, Ukraine, 49102
Completed
155
SI Grigoriev Institute for Medical Radiology National Academy of Medical Science of Ukraine
Kharkiv, Ukraine, 61024
Completed
156
Khmelnitskiy Regional Hospital, Hematology Department
Khmelnitskiy, Ukraine, 29000
Completed
157
State Institution Scientific Center for Radiation Medicine Academy of Medical Sciences of Ukraine
Kiev, Ukraine, 03115
Completed
158
Institute of Blood Pathology and Transfusion Medicine of AMS of Ukraine
Lviv, Ukraine, 79044
Active, Not Recruiting
159
Vinnytsya Regional Clinical Hospital named after M.I.Pirogov
Vinnitsa, Ukraine, 21018
Completed
160
University Hospitals Birmingham NHS Trust,
Birmingham, United Kingdom, B15 2TH
Completed
161
Royal Bournemouth Hospital
Bournemouth, United Kingdom, BH7 7DW
Completed
162
Colchester Hospital University NHS
Colchester, United Kingdom, CO4 5JL
Completed
163
Beatson West Of Scotland Cancer Centre
Glasgow, United Kingdom, G12 0YN
Completed
164
St James's Institute of Oncology
Leeds, United Kingdom, LS9 7TF
Completed
165
Leicester Royal Infirmary - Haematology
Leicester, United Kingdom, LE1 5WW
Completed
166
St Bartholomew's Hospital - Dept of Haematology
London, United Kingdom, EC1A 7BE
Completed
167
University College London Hospitals NHSFT
London, United Kingdom, NW1 2BU
Completed
168
Kings College Hospital
London, United Kingdom, SE5 9RS
Completed
169
Christie Hospital
Manchester, United Kingdom, 00000
Completed
170
Freeman Hospital Newcastle upon Tyne Hosptials NHS Foundation Trust
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
171
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom, NG5 1PB
Completed
172
Derriford Hospital
Plymouth, United Kingdom, PL6 8DH
Completed
173
Royal Hallamshire Hospital
Sheffield, United Kingdom, S10 2JF
Completed
174
Southampton General Hospital
Southampton, United Kingdom, SO16 6YD
Completed
175
Royal Marsden Hospital (Sutton)
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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