Actively Recruiting
Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies
Led by Galapagos NV · Updated on 2026-02-05
546
Participants Needed
6
Research Sites
772 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a long-term follow-up study for participants treated with Galapagos (GLPG) CAR T-cell therapies to evaluate the long-term safety and efficacy of GLPG CAR T-cell products for 15 years post infusion. Per Health Authorities guidelines for gene therapy medicinal products that utilize integrating vectors (e.g. lentiviral vectors), long term safety and efficacy follow up of treated patients is required. The purpose of this study is to monitor all participants exposed to GLPG CAR T-cell therapies for 15 years following their last CAR T-cell infusion to assess the risk of delayed adverse events (AEs) and the long-term benefit/risk profile and to monitor for replication-competent lentivirus (RCL) and CAR-T cell persistence.
CONDITIONS
Official Title
Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have been treated with a Galapagos CAR T-cell therapy in a clinical trial or Managed Access Program
You will not qualify if you...
- There are no exclusion criteria for this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Antwerp University Hospital
Edegem, Belgium, 2650
Actively Recruiting
2
Centre Hospitalier Universitaire (CHU) De Liège
Liège, Belgium, 4032
Actively Recruiting
3
Amsterdam UMC
Amsterdam, Netherlands, 1081 HV
Actively Recruiting
4
Academisch Medisch Centrum
Amsterdam, Netherlands, 1105 AZ
Actively Recruiting
5
Leids University Medical Center (LUMC)
Leiden, Netherlands, 2333 ZA
Actively Recruiting
6
Hospital Clinic De Barcelona
Barcelona, Spain, 08036
Actively Recruiting
Research Team
G
Galapagos Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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