Long-Term Effects of Time-Restricted Eating on Heart and Metabolic Health in Adults with Metabolic Syndrome

What this Trial Is About

Researchers are studying the effects of time-restricted eating TRE on patients with metabolic syndrome who have high blood pressure and at least two other metabolic risk factors, such as increased waist size, abnormal cholesterol, high triglycerides, or elevated fasting glucose. The study focuses on people who typically eat for more than 12 hours daily and aims to better understand how limiting eating to a 10-hour window daily may impact cardiometabolic health over a long period. Participants are randomly assigned to one of two groups one follows a daily 10-hour eating window combined with standard care and nutritional counseling, while the other continues their usual lifestyle without the eating window but also receives nutritional counseling. The study lasts 54 weeks and involves logging all food and drink intake using a smartphone app. Both groups receive lifestyle coaching and track their calories using the app. Throughout the study, researchers will measure height, weight, waist size, and blood pressure. Blood tests will check blood sugar control, insulin, lipids, and detailed cholesterol profiles. Participants will wear a continuous glucose monitor and an activity tracker at the start, six months, and the end of the study to monitor blood sugar, physical activity, and sleep. Body composition will be evaluated by DEXA scans, and an oral glucose tolerance test will assess how the body handles sugar. The main outcome is change in glucose levels after 54 weeks, along with other measures like cholesterol, insulin sensitivity, bone density, muscle mass, and body fat.

Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health