Actively Recruiting
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-07-29
35
Participants Needed
1
Research Sites
124 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD. STUDY DESIGN: The investigators will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinical assessment of motor and non-motor symptoms (including cognitive testing), as well as 11C-UCB-J PET-CT (targeting synaptic density marker SV2A), 18F-FE-PE2I PET-CT (targeting DAT) and brain MRI.
CONDITIONS
Official Title
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participation in study S61477 (NCT04243304)
You will not qualify if you...
- Neuropsychiatric diseases unrelated to Parkinson's disease for Parkinson's patients
- Major internal medical diseases
- History of alcohol or drug abuse
- Relevant abnormalities on brain MRI
- Contraindications for MRI
- Pregnancy or breastfeeding
- Previous participation in research studies involving ionizing radiation exceeding 1 mSv in the past 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
W
Wim Vandenberghe, MD, PhD
CONTACT
J
Jolien Van Opstal, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here