Long-term Observation of Participants With Mood Disorders

What this Trial Is About

Researchers are following up with adults who previously participated in studies on mood disorders such as depression, bipolar disorder, and suicide risk at the National Institute of Mental Health. This research aims to understand the long-term effects of these conditions and the ongoing treatments participants may be receiving. They plan to identify factors that predict long-term depression, suicide attempts, and ketamine use. The study is conducted entirely remotely in two phases: an online phase and a telephone phase. In Phase 1, participants complete online surveys about their current mental health symptoms and treatments, taking about 30 minutes. Those interested may proceed to Phase 2, which involves a 1 to 4 hour phone interview covering detailed questions about mood, treatments, and medication use since leaving previous NIH studies. Participants provide information through surveys and phone interviews, with the option to skip any questions. Researchers will link this data with existing clinical and biological records collected over the past 20 years. The main outcome measured is the score on the Beck Depression Inventory. Secondary outcomes include self-reported suicide attempts, ketamine use, and suicide deaths identified from national data. Participation lasts about 20 minutes to 4 hours in total, with no in-person visits required.

Long-term Observation of Participants With Mood Disorders