Actively Recruiting
Perpetual Observational Study of Acute Respiratory Infections in Primary Care Across Europe
Led by European Clinical Research Alliance for Infectious Diseases (ECRAID) · Updated on 2026-04-14
2000
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
E
European Clinical Research Alliance for Infectious Diseases (ECRAID)
Lead Sponsor
U
UMC Utrecht
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a long-term observational study across Europe to understand acute respiratory infections (ARI) in adults and children visiting primary care. The study aims to describe how ARI presents and is managed in community care, including infections caused by known and emerging respiratory pathogens. This research will help prepare for future clinical trials by building a research-ready infrastructure in primary care settings. Participants in this study may be part of one of three study protocols: POS-ARI-PC AUDIT, POS-ARI-PC CORE, or the embedded POS-ARI-PC-001 study. The AUDIT protocol involves anonymous registration of ARI cases presenting at primary care facilities. The CORE protocol includes detailed observational study with patient sampling and 28-day follow-up. The embedded POS-ARI-PC-001 study focuses on older adults or those with long-term health conditions and includes swab collection and follow-up procedures. During participation, patients will complete questionnaires about their symptoms and provide throat/nose swabs for analysis. They will be asked to report daily on their health status for up to 14 days using online or paper diaries. Researchers will also review clinical outcomes and hospital referrals up to 28 days after enrollment. Some participants may join optional interviews to share their experiences. The study collects data on illness severity, diagnosis, management, medication use, and return to daily activities to better inform future care and research.
CONDITIONS
Brief Title
A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of any age consulting with symptoms suggestive of acute lower respiratory infection with cough lasting less than 28 days
- Patients with symptoms of acute upper respiratory infection with sore throat and/or coryza lasting less than 14 days
- Patients suspected of COVID-19, influenza, or RSV
- Willingness and ability to provide informed consent and comply with study procedures (for CORE protocol)
You will not qualify if you...
- Withdrawal of consent for anonymous data collection by the patient
- Inability to comply with study procedures due to language barriers without assistance, serious psychiatric disorder, or terminal illness
- Symptoms of presumed non-infective origin
- Requirement for hospital admission on the day of inclusion (except in embedded POS-ARI-PC-001 study where hospitalisation may be allowed if timing permits)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day 0
Participants undergo study-specific sampling including a combined throat/nose swab and complete a questionnaire about their symptoms and health status at inclusion.
1 visit (in-person)
Duration - 28 days
Participants report daily on their symptoms and recovery for up to 14 days using an online or paper diary, with possible telephone follow-up if needed. Their general practitioner is contacted after 28 days to collect information about consultations and hospital referrals.
Daily symptom reporting for 14 days and follow-up contact at day 28
Duration - After day 28
A small subset of participants may be invited for interviews to discuss their experiences and perspectives on the research process and respiratory infections.
1 interview (remote or in-person)
Trial Site Locations
Total: 3 locations
1
Universiteit Antwerpen
Antwerp, Belgium
Actively Recruiting
2
Centre Hospitalier Universitaire de Limoges
Limoges, France
Actively Recruiting
3
University of Oxford
Oxford, United Kingdom
Actively Recruiting
Research Team
C
Christopher Butler
N
Nguyen Tran
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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