Long Term Outcome of Esophageal Atresia: Multi-Omic Profiles in Adolescents

What this Trial Is About

Researchers are studying adolescents aged 13 to 14 who were born with esophageal atresia, a birth defect where the esophagus is interrupted and ends in a dead end. Surgery is required soon after birth to restore esophagus continuity, but many children continue to experience health issues such as acid reflux, eating difficulties, breathing problems, and growth challenges throughout life. This study aims to assess the long-term outcomes and develop detailed molecular profiles of esophageal tissue and blood samples from this rare condition. The study includes two groups: adolescents with esophageal atresia and a control group without the condition. Participants undergo upper gastrointestinal endoscopy with biopsy sampling as part of their usual care. Quality of life questionnaires designed specifically for this research, including the Pediatric Quality of Life Inventory and EA-QoL, are used. Clinical and molecular data from tissue and blood samples will be analyzed together to understand disease impact and molecular changes. Data will be stored and shared through the France Cohortes platform. Participants will have their gastroesophageal reflux disease (GERD) status assessed along with measures of quality of life, nutrition, and respiratory health. Researchers will analyze molecular profiles from plasma and esophageal biopsies, and look at factors associated with GERD from birth through adolescence. Participation involves clinical data collection, questionnaires, and biological sampling during routine care. Data from this study will contribute to understanding the long-term effects of esophageal atresia and aid future research.

Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence