Actively Recruiting
Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Led by Henan Institute of Cardiovascular Epidemiology · Updated on 2025-09-18
210
Participants Needed
1
Research Sites
298 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials demonstrated a perioperative cardioprotective effect of RIPC (reduced troponin levels), but did not find that a single preoperative RIPC improved long-term outcomes of coronary artery bypass grafting(CABG).The effect of a single RIPC before CABG may be too short. This study aims to investigate whether long-term RIPC improved myocardial perfusion in patients 3 months and 6 months after CABG surgery , and to detect changes in blood vascular endothelial growth factor, Nitrc Oxide, adenosine，and Endothelin-1, and to observe MACCE event rates at 12 months.
CONDITIONS
Official Title
Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with three coronary artery lesions scheduled for coronary artery bypass grafting (CABG) surgery
You will not qualify if you...
- Patients unable to tolerate remote ischemic preconditioning (RIPC)
- Peripheral vascular disease affecting upper limbs
- Acute myocardial infarction complicated with cardiogenic shock within the past 30 days
- Emergency cases
- Severe structural heart disease and severe arrhythmia
- Uncontrolled severe hypertension with systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥120 mmHg
- Severe liver, kidney, or lung disease
- Mental disorders preventing cooperation
- Inability to provide informed consent
- Current use of glibenclamide or nicorandil medications
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Fuwai central China cardiovascular Hospital
Zhengzhou, Henan, China
Actively Recruiting
Research Team
Q
Quan Guo, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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