Actively Recruiting
Long-term Result of DTPA (Diethylenetriamine Pentaacetate) Chelation for Gadolinium Deposition Disease
Led by Stanford University · Updated on 2025-10-07
50
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is aimed at describing the degree of benefit, if any, and the adverse effects, if any, from receiving 5 or more treatment sessions of Gadolinium Deposition Disease using two-day chelation treatment with the chelating agents Calcium Diethylenetriamine pentaacetate (Ca-DTPA) and Zinc Diethylenetriamine pentaacetate (Zn-DTPA).
CONDITIONS
Official Title
Long-term Result of DTPA (Diethylenetriamine Pentaacetate) Chelation for Gadolinium Deposition Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Diagnosis of Gadolinium Deposition Disease confirmed by a treating doctor and investigator review
- Presence of at least 3 of 8 specific symptoms (cognitive disturbance, extremity pain, arthralgia, chest wall pain, skin pain, headache, skin induration, skin hyperpigmentation)
- Unprovoked 24-hour gadolinium urine excretion above the laboratory norm at least 28 days after symptom-inducing MRI
- Completed five or more 2-day chelation treatments with Ca-DTPA and Zn-DTPA
- At least 2 weeks have passed since the last chelation treatment
- No more than 2 years have passed since last DTPA chelation
You will not qualify if you...
- Not fluent in written and spoken English
- Significant hearing impairment that limits telephone communication
- Prisoner status
- Unable to provide informed consent
- Participation in other pharmacological treatment studies for GDD besides DTPA chelation (brief pre- or post-DTPA chelation to prevent symptom flare is allowed)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University Medical Center
Stanford, California, United States, 94305
Actively Recruiting
Research Team
L
Lorrin M Koran, MD
CONTACT
J
Jarrod Ehrie, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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