Actively Recruiting

Phase 2
All Genders
NCT06914908

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Led by Sanofi · Updated on 2026-04-28

64

Participants Needed

24

Research Sites

298 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a single-arm extension study to investigate the long-term safety, tolerability, and efficacy of lunsekimig in adult participants with inadequately controlled CRSwNP who have completed a previous lunsekimig CRSwNP clinical study (also referred to as the parent study ACT18207). The study duration will be up to approximately 56 weeks per participant, 52 weeks of treatment period, and 4 weeks of follow-up.

CONDITIONS

Official Title

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants who have completed the treatment and follow-up periods in a previous lunsekimig CRSwNP study, including the end of study visit
  • Currently receiving therapy with mometasone furoate nasal spray
  • Able and willing to participate in this extension study and comply with all study visits and procedures
Not Eligible

You will not qualify if you...

  • Prior allergic reaction to lunsekimig or its ingredients, or other allergies that contraindicate study participation
  • Taking part in any other clinical study besides the previous lunsekimig study
  • Experienced adverse events related to lunsekimig in the previous study that suggest continued treatment may pose an unreasonable risk

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 24 locations

1

Modena Allergy + Asthma- Site Number : 8400005

La Jolla, California, United States, 92037

Actively Recruiting

2

Sacramento Ear Nose & Throat - Roseville- Site Number : 8400003

Roseville, California, United States, 95661

Actively Recruiting

3

Treasure Valley Medical Research- Site Number : 8400002

Boise, Idaho, United States, 83706

Active, Not Recruiting

4

Essential Medical Research- Site Number : 8400020

Tulsa, Oklahoma, United States, 74137

Actively Recruiting

5

McGovern Medical School - UT Physicians Dermatology - Bellaire Station- Site Number : 8400017

Bellaire, Texas, United States, 77401

Actively Recruiting

6

Pharmaceutical Research & Consulting- Site Number : 8400004

Dallas, Texas, United States, 75231

Actively Recruiting

7

ENT Associates of Texas - McKinne- Site Number : 8400014

McKinney, Texas, United States, 75070

Actively Recruiting

8

Alamo ENT Associates- Site Number : 8400001

San Antonio, Texas, United States, 78258

Actively Recruiting

9

Eastern Virginia Medical School (EVMS) Medical Group- Site Number : 8400008

Norfolk, Virginia, United States, 23510

Actively Recruiting

10

Investigational Site Number : 0320002

Rosario, Santa Fe Province, Argentina, 2000

Active, Not Recruiting

11

Investigational Site Number : 0320001

Buenos Aires, Argentina, 1121

Active, Not Recruiting

12

Investigational Site Number : 0320003

Mendoza, Argentina, 5500

Active, Not Recruiting

13

Investigational Site Number : 0560002

Ghent, Belgium, 9000

Active, Not Recruiting

14

Investigational Site Number : 0560001

Leuven, Belgium, 3000

Active, Not Recruiting

15

Investigational Site Number : 1000001

Sofia, Bulgaria, 1612

Actively Recruiting

16

Investigational Site Number : 6160004

Poznan, Greater Poland Voivodeship, Poland, 60-693

Actively Recruiting

17

Investigational Site Number : 6160002

Krakow, Lesser Poland Voivodeship, Poland, 30-033

Actively Recruiting

18

Investigational Site Number : 6160007

Wroclaw, Lower Silesian Voivodeship, Poland, 50-750

Actively Recruiting

19

Investigational Site Number : 6160001

Warsaw, Masovian Voivodeship, Poland, 00-909

Actively Recruiting

20

Investigational Site Number : 6160005

Warsaw, Masovian Voivodeship, Poland, 02-507

Actively Recruiting

21

Investigational Site Number : 6160003

Katowice, Silesian Voivodeship, Poland, 40-611

Actively Recruiting

22

Investigational Site Number : 8260004

Gloucester, Gloucestershire, United Kingdom, GL1 3NN

Actively Recruiting

23

Investigational Site Number : 8260003

Manchester, United Kingdom, M13 9wl

Active, Not Recruiting

24

Investigational Site Number : 8260001

Newcastle upon Tyne, United Kingdom, NE7 7DN

Active, Not Recruiting

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Research Team

T

Trial Transparency email recommended (Toll free for US & Canada)

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study | DecenTrialz