Actively Recruiting
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Led by Apogee Therapeutics, Inc. · Updated on 2026-04-30
350
Participants Needed
45
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, double-blind, Long-Term Extension (LTE) study to evaluate the long-term safety and efficacy of APG777 in patients with moderate-to-severe AD who have completed treatment in an APG777 Parent Study (NCT06395948). The LTE study will consist of 3 periods: 1) Screening Visit will coincide with the last visit of the Maintenance Period in the Parent Study 2) Extended Treatment Period 3) Post-treatment Follow-up Period. This study will be conducted in participants with atopic dermatitis (AD) who completed the Treatment Period in a prior APG777 study and who, in the opinion of the Investigator, would benefit from long-term treatment with APG777.
CONDITIONS
Official Title
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completed the treatment period in a prior APG777 study and were compliant with the study protocol
- Considered by the Investigator to benefit from long-term treatment with APG777
- Use the same non-prescription non-medicated emollient or moisturizer from the last day of the Parent Study throughout the LTE study
You will not qualify if you...
- Developed an adverse event during the Parent Study that may make continued APG777 treatment unsafe
- Terminated early or permanently discontinued the study drug during the Parent Study
- Used any prohibited medications from the Parent Study through the LTE study screening visit
- Have dermatologic conditions or comorbidities that could confuse the AD diagnosis or interfere with study assessments
- Additional protocol-defined inclusion or exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 45 locations
1
Investigational Site
Fountain Valley, California, United States, 92708
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2
Investigational Site
Los Angeles, California, United States, 90024
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3
Investigational Site
Coral Gables, Florida, United States, 33134
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4
Investigational Site
Jacksonville, Florida, United States, 32256
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5
Investigational Site
Margate, Florida, United States, 33063
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6
Investigational Site
Douglasville, Georgia, United States, 30135
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7
Investigational Site
Skokie, Illinois, United States, 60077
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8
Investigational Site
Bowling Green, Kentucky, United States, 42101
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9
Investigational Site
Detroit, Michigan, United States, 48202
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10
Investigational Site
Troy, Michigan, United States, 48084
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11
Investigational Site
New York, New York, United States, 10023
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12
Investigational Site
Wilmington, North Carolina, United States, 28403
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13
Investigational Site
Boardman, Ohio, United States, 44512
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14
Investigational Site
Mason, Ohio, United States, 45040
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15
Investigational Site
Portland, Oregon, United States, 97223
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16
Investigational Site
Pittsburgh, Pennsylvania, United States, 15213
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17
Investigational Site
Charleston, South Carolina, United States, 29425
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18
Investigational Site
Nashville, Tennessee, United States, 37215
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19
Investigational Site
Dallas, Texas, United States, 75230
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20
Investigational Site
Frisco, Texas, United States, 75235
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21
Investigational Site
San Antonio, Texas, United States, 78213
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22
Investigational Site
Calgary, Alberta, Canada, T2J 7E1
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23
Investigational Site
Edmonton, Alberta, Canada, T5J 3S9
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24
Investigational Site
Fredericton, Brunswick, Canada, E3B 1G9
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25
Investigational Site
Ajax, Ontario, Canada, L1S 7K8
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26
Investigational Site
Markham, Ontario, Canada, L3P 1X3
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27
Investigational Site
Mississauga, Ontario, Canada, L4Y 4C5
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28
Investigational Site
Peterborough, Ontario, Canada, K9J 5K2
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29
Investigational Site
Toronto, Ontario, Canada, M3B 0A7
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30
Investigational Site
Toronto, Ontario, Canada, M4E 2Y9
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31
Investigational Site
Toronto, Ontario, Canada, M4W 2N4
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32
Investigational Site
Montreal, Quebec, Canada, H2X 2V1
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33
Investigational Site
Québec, Quebec, Canada, G1V 4X7
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34
Investigational Site
Blankenfelde-Mahlow, Brandenburg, Germany, 15831
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35
Investigational Site
Wroclaw, Lower Silesian Voivodeship, Poland, 50-450
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36
Investigational Site
Wroclaw, Lower Silesian Voivodeship, Poland, 51-503
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37
Investigational Site
Lublin, Lublin Voivodeship, Poland, 20-573
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38
Investigational Site
Warsaw, Masovian Voivodeship, Poland, 01-595
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39
Investigational Site
Warsaw, Masovian Voivodeship, Poland, 02-482
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40
Investigational Site
Gdansk, Pomeranian Voivodeship, Poland, 80-546
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41
Investigational Site
Katowice, Silesian Voivodeship, Poland, 40-600
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42
Investigational Site
Sosnowiec, Silesian Voivodeship, Poland, 41-218
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43
Investigational Site
Szczecin, West Pomeranian Voivodeship, Poland, 71-500
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44
Investigational Site
Krakow, Woj. Małopolskie, Poland, 30-727
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45
Investigational Site
Lodz, Poland, 90-237
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Research Team
S
Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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