Actively Recruiting
A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.
Led by Pfizer · Updated on 2026-04-28
140
Participants Needed
41
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to learn about long-term safety and long-term effects of the study medicine (called ritlecitinib) for the potential treatment of severe alopecia areata, a condition that causes hair loss. This study is seeking participants who have: * previously completed one of Pfizer's pediatric studies for Alopecia Areata (B7981027 or B7981031). * at least 50% scalp hair loss due to alopecia areata (for participants enrolling from the study B7981031). * received varicella vaccination (2 doses) or have been infected by varicella zoster virus before based on blood test reports. All participants in this study will receive the study medicine (ritlecitinib). Participants who received ritlecitinib higher or lower doses in the parent Study B7981027 will continue receiving the same ritlecitinib dose in this trial. Participants who received placebo in the parent Study B7981027 and all participants from parent Study B7981031 will receive either higher or lower dose of ritlecitinib in this trial. The study medicine is a capsule that is taken by mouth. It is taken 1 time each day at home. The study will help see if ritlecitinib is safe and effective. Participants will take part in this study for a duration of up to 3 years (36 months). During this time, they will have 17 study visits at the study clinic. The study team will also call participants once a month over the phone.
CONDITIONS
Official Title
A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with alopecia areata (including alopecia totalis and alopecia universalis) who completed studies B7981027 or B7981031
- Participants from Study B7981031 must have at least 50% scalp hair loss (SALT score 6550) at Screening and Baseline visits
You will not qualify if you...
- Participants from Study B7981027 with 64 days between last dose and first visit of this study who had safety events requiring permanent discontinuation
- Participants discontinued from Study B7981027 for reasons other than safety must have resolved those issues before enrolling
- Participants from Study B7981031 or from Study B7981027 with more than 30 days between last dose and first visit who had safety events requiring permanent discontinuation
- Any current or past malignancies or lymphoproliferative disorders
- Untreated or inadequately treated active or latent tuberculosis infection
- History of severe or serious cytomegalovirus, herpes zoster, or disseminated herpes simplex infections
- Infection with hepatitis B or hepatitis C virus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 41 locations
1
California Dermatology & Clinical Research Institute
Encinitas, California, United States, 92024
Actively Recruiting
2
Pediatric Skin Research
Miami, Florida, United States, 33156
Actively Recruiting
3
D&H Tamarac Research Center
Tamarac, Florida, United States, 33321
Not Yet Recruiting
4
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States, 46250
Actively Recruiting
5
Kindred Hair and Skin Center
Marriottsville, Maryland, United States, 21104
Not Yet Recruiting
6
Michigan Dermatology Institute
Waterford, Michigan, United States, 48328
Not Yet Recruiting
7
Ear, Nose & Throat Consultants, LLC
Omaha, Nebraska, United States, 68144
Actively Recruiting
8
Skin Specialists, PC dba Schlessinger MD
Omaha, Nebraska, United States, 68144
Actively Recruiting
9
Complete Behavior Health (Dr. Brittany Marshall, Licensed Psychologist)
Papillion, Nebraska, United States, 68046
Actively Recruiting
10
University of New Mexico Health Sciences Center
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
11
University of New Mexico-IDS Pharmacy
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
12
Regents of the University of New Mexico
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
13
Equity Medical, LLC
The Bronx, New York, United States, 10455
Not Yet Recruiting
14
Northwest Dermatology Institute
Portland, Oregon, United States, 97210
Actively Recruiting
15
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Not Yet Recruiting
16
Medical University of South Carolina Department of Dermatology and Dermatologic Surgery
Charleston, South Carolina, United States, 29425
Not Yet Recruiting
17
3A Research
El Paso, Texas, United States, 79902
Actively Recruiting
18
Texas Dermatology and Laser Specialists
San Antonio, Texas, United States, 78218
Actively Recruiting
19
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
20
Prof. MUDr. Petr Arenberger, DrSc., MBA
Prague, Czechia, 11000
Not Yet Recruiting
21
Hospices Civils de Lyon - Hopital Femme Mere Enfant
Bron, France, 69500
Not Yet Recruiting
22
CHU de Dijon Bourgogne
Dijon, France, 21079
Not Yet Recruiting
23
GHICL - Service d'investigation - Recherche clinique
Lille, France, 59000
Not Yet Recruiting
24
Hôpital Saint Vincent de Paul
Lille, France, 59020
Not Yet Recruiting
25
Centre Hospitalier Universitaire de Nice
Nice, France, 06202
Not Yet Recruiting
26
Hôpitaux Drôme Nord
Romans-sur-Isère, France, 26100
Not Yet Recruiting
27
Centre Hospitalier Universitaire de Toulouse - Hôpital Larrey
Toulouse, France, 31400
Not Yet Recruiting
28
Tohoku University Hospital
Sendai, Miyagi, Japan, 980-8574
Not Yet Recruiting
29
Hamamatsu University Hospital
Hamamatsu, Shizuoka, Japan, 431-3192
Actively Recruiting
30
Kyorin University Hospital
Mitaka, Tokyo, Japan, 181-8611
Not Yet Recruiting
31
Osaka Metropolitan University Hospital
Osaka, Japan, 545-8586
Actively Recruiting
32
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska
Wroclaw, Lower Silesian Voivodeship, Poland, 50-566
Not Yet Recruiting
33
DERMEDIC Iwona Zdybska
Lublin, Lublin Voivodeship, Poland, 20-607
Not Yet Recruiting
34
Klinika Osipowicz & Turkowski
Warsaw, Masovian Voivodeship, Poland, 00-716
Not Yet Recruiting
35
Państwowy Instytut Medyczny MSWiA
Warsaw, Masovian Voivodeship, Poland, 02-507
Not Yet Recruiting
36
Provita Poliklinika
Warsaw, Masovian Voivodeship, Poland, 02-647
Not Yet Recruiting
37
Klinika Ambroziak Dermatologia
Warsaw, Masovian Voivodeship, Poland, 02-953
Not Yet Recruiting
38
Royalderm Agnieszka Nawrocka
Warsaw, Masovian Voivodeship, Poland, 02-962
Not Yet Recruiting
39
Centrum Medyczne Angelius Provita
Katowice, Silesian Voivodeship, Poland, 40-611
Not Yet Recruiting
40
Uniwersytecki Szpital kliniczny im. F. Chopina w Rzeszowie
Rzeszów, Poland, 35-055
Not Yet Recruiting
41
Dermoklinika - Centrum Medyczne spółka cywilna M. Kierstan, J. Narbutt, A. Lesiak
Lodz, Łódź Voivodeship, Poland, 90-436
Not Yet Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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