Actively Recruiting
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
Led by Pfizer · Updated on 2026-04-07
500
Participants Needed
31
Research Sites
324 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This 24-month study will assess the long-term safety and efficacy of liquid abrocitinib oral suspension with or without topical medications in children 2 years of age or older with moderate-to-severe atopic dermatitis. The study will enroll two groups: participants who have completed other abrocitinib studies and participants who have never participated in abrocitinib studies.
CONDITIONS
Official Title
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 2 to less than 12 years who completed prior abrocitinib studies (extension cohort)
- Female participants of childbearing potential must use effective contraception; males have no contraception requirements
- Children aged 6 to less than 12 years who have not participated in prior abrocitinib studies (de novo cohort)
- Documented chronic atopic dermatitis for at least 6 months, confirmed by criteria
- Moderate-to-severe atopic dermatitis at baseline (specific clinical measures required)
- History of inadequate response to topical therapies for atopic dermatitis
- Body weight of at least 15 kg
You will not qualify if you...
- Any medical or psychiatric condition that increases risk or makes participation unsafe, including recent suicidal ideation or behavior
- For extension cohort: ongoing safety concerns from parent studies or early discontinuation in parent studies
- Use of prohibited concomitant treatments or live vaccines during study and for 6 weeks after
- For de novo cohort: recent or active infections requiring treatment or hospitalization
- History of disseminated or recurrent herpes infections
- Infection with HIV, hepatitis B or C, or active/inadequately treated tuberculosis
- Skin conditions like psoriasis or lupus that interfere with evaluation
- History of skeletal dysplasia, retinal detachment, blood disorders, or malignancies
- Immunodeficiency or family history of hereditary immunodeficiency
- Prior systemic JAK inhibitor treatment for atopic dermatitis
- Recent live attenuated vaccinations or need for such vaccines during study
- Use of strong CYP2C19 and CYP2C9 enzyme inhibitors or inducers
- Recent investigational drug use within 30 days or 5 half-lives
- Abnormal liver, kidney, or blood test results beyond specified thresholds
- Investigator site staff, their family, and sponsor employees involved in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 31 locations
1
Cahaba Dermatology & Skin Health Center
Birmingham, Alabama, United States, 35244
Actively Recruiting
2
Arkansas Research Trials
North Little Rock, Arkansas, United States, 72117
Actively Recruiting
3
Investigational Drug Service - Rady Childrens Hospital-San Diego
San Diego, California, United States, 92123
Not Yet Recruiting
4
University of California, San Diego/ Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Not Yet Recruiting
5
Solutions Through Advanced Research
Jacksonville, Florida, United States, 32256
Actively Recruiting
6
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States, 46250
Not Yet Recruiting
7
Tribe Clinical Research, LLC
Greenville, South Carolina, United States, 29607
Actively Recruiting
8
Hunan Children's Hospital
Changsha, Hunan, China, 410007
Not Yet Recruiting
9
Dermatology Hospital of Jiangxi Province
Nanchang, Jiangxi, China, 330000
Not Yet Recruiting
10
Hangzhou Third People's Hospital
Hangzhou, Zhejiang, China, 310009
Not Yet Recruiting
11
Xinhua Hospital Affiliated to Shanghai JiaoTong University School of Medicine
Shanghai, China, 200092
Actively Recruiting
12
Universitätsklinikum Münster
Münster, North Rhine-Westphalia, Germany, 48149
Not Yet Recruiting
13
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, Saxony, Germany, 01307
Not Yet Recruiting
14
Pécsi Tudományegyetem Klinikai Központ
Pécs, Baranya, Hungary, 7632
Actively Recruiting
15
Clinexpert Kft.
Budapest, Pest County, Hungary, 1033
Actively Recruiting
16
Queen's square Medical Facilities Queen's square Dermatology and Allergology
Yokohama, Kanagawa, Japan, 220-6208
Actively Recruiting
17
Dermatology and Ophthalmology Kume Clinic
Sakai, Osaka, Japan, 593-8324
Actively Recruiting
18
Sasamoto Children's Clinic
Setagaya-ku, Tokyo, Japan, 157-0066
Actively Recruiting
19
Fukuoka National Hospital
Fukuoka, Japan, 811-1394
Actively Recruiting
20
Eukarya Pharmasite S.C.
Monterrey, Nuevo León, Mexico, 64718
Not Yet Recruiting
21
Arké SMO S.A de C.V
Veracruz, Veracruz Ignacio de LA Llave, Mexico, 91900
Not Yet Recruiting
22
Servicios Hospitalarios de Mexico S.A. DE C.V.
Chihuahua City, Mexico, 31238
Not Yet Recruiting
23
LUXDERM Specjalistyczny Gabinet Dermatologiczny prof. dr hab. n. med. Dorota Krasowska
Lublin, Lublin Voivodeship, Poland, 20-573
Not Yet Recruiting
24
Centrum Medyczne Evimed
Warsaw, Masovian Voivodeship, Poland, 02-625
Not Yet Recruiting
25
DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gebska
Chorzów, Silesian Voivodeship, Poland, 41-500
Actively Recruiting
26
Centrum Medyczne Angelius Provita
Katowice, Silesian Voivodeship, Poland, 40-611
Not Yet Recruiting
27
Dermoklinika - Centrum Medyczne spółka cywilna M. Kierstan, J. Narbutt, A. Lesiak
Lodz, Łódź Voivodeship, Poland, 90-436
Not Yet Recruiting
28
Dermedic Jacek Zdybski
Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, Poland, 27-400
Actively Recruiting
29
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [LA Coruña], Spain, 15706
Not Yet Recruiting
30
Hospital General de Granollers
Granollers, Barcelona, Spain, 08402
Not Yet Recruiting
31
Hospital Universitario Miguel Servet
Zaragoza, Spain, 50009
Not Yet Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here