Actively Recruiting
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
Led by Mayo Clinic · Updated on 2026-03-03
30
Participants Needed
1
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
CONDITIONS
Official Title
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI 40 - 50 kg/m2.
- No active physical illness that would interfere with mobility or weight loss after bariatric surgery.
You will not qualify if you...
- Diagnosis of Type 1 or Type 2 Diabetes or fasting plasma glucose ≥126 mg/dL.
- Active coronary artery disease.
- Participation in structured exercise more than 2 times per week for 30 minutes or longer.
- Smoking.
- Use of medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids).
- Renal insufficiency with serum creatinine > 1.5 mg/dL.
- Chronic active liver disease (Bilirubin > 17 mmol/L, AST > 144 IU/L, or ALT > 165 IU/L).
- Pregnancy or breastfeeding.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 559055
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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