Actively Recruiting
Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery
Led by Imperial College London · Updated on 2025-02-19
100
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
C
Cancer Research UK
Collaborating Sponsor
AI-Summary
What this Trial Is About
Oesophagogastric cancer (cancer of the gullet and stomach) is the fifth most common cancer in England and Wales with 16,000 new cases diagnosed every year. Survival rates are poor with only 15% surviving beyond 5 years. There is also increasing research to understand the cancer biology and factors allowing cancers to progress. It is likely there is a relationship between the cancer-specific microbiome, cells related to inflammation, which promotes cancer progression. The BIORESOURCE 1 study has established a comprehensive resource of matched samples from patients with oesophageal and gastric cancer. This longitudinal study aims to obtain further matched biosamples in the follow-up period after cancer surgery to find biomarkers that may predict treatment response, recurrence and/or long term prognosis.
CONDITIONS
Official Title
Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-90 years at the time of initial recruitment
- Biopsy-proven gastric or oesophageal adenocarcinoma
- Previously recruited into BIORESOURCE 1 study
You will not qualify if you...
- Oesophageal squamous cell carcinoma
- Previous oesophageal and gastric resection
- History of another cancer within five years or new cancer during sampling period
- Co-morbidities preventing breath collection
- Unable or unwilling to provide informed written consent
- Pregnant women
AI-Screening
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Trial Site Locations
Total: 1 location
1
Imperial College Healthcare NHS Trust
London, United Kingdom
Actively Recruiting
Research Team
B
Bhamini Vadhwana, MRCS, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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