Actively Recruiting
Longitudinal Assessment of Traumatic Microvascular Injury-2
Led by University of Pennsylvania · Updated on 2026-03-31
110
Participants Needed
1
Research Sites
264 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about changes in the brain of patients over the first 3 years following a traumatic brain injury (TBI). The main question it aims to answer are: \- How TBI effect the rate of brain tissue loss compare to healthy brain Participants will give blood samples, complete MRI scans, and neuropsychological assessment measures. Researchers will compare results between healthy control group and TBI group to determine changes in injured brains.
CONDITIONS
Official Title
Longitudinal Assessment of Traumatic Microvascular Injury-2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65, inclusive
- History of non-penetrating traumatic brain injury of at least moderate severity confirmed by trauma-related abnormality on CT scan
- Injury caused by high-velocity, high-impact events such as motor vehicle accidents or falls from height
- Immediate loss of consciousness after injury
You will not qualify if you...
- History of disabling neurological or psychiatric diseases like epilepsy, brain tumors, meningitis, cerebral palsy, encephalitis, brain abscesses, vascular malformations, cerebrovascular disease, Alzheimer's disease, multiple sclerosis, or HIV-encephalitis
- Pre-existing disability that would interfere with outcome assessments
- No pupillary responses in both eyes
- Penetrating traumatic brain injury
- Elevated intracranial pressure (≥ 17 mmHg)
- Contraindications to contrast-enhanced MRI such as ferromagnetic implants, pregnancy, allergy to gadolinium contrast, renal impairment (GFR < 60 ml/g/m3), claustrophobia, or hemodynamic instability
- Prisoners or patients in police custody
- Objective lung disease with elevated PaCO2 or venous serum bicarbonate based on clinical labs
- Requirement for portable oxygen at enrollment
- Chronic heart failure or severe pulmonary disease
- Current substance abuse preventing participation and follow-up
- Any medical or other disability preventing completion of study procedures as determined by investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19041
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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