Actively Recruiting
Longitudinal Characterization of Microbial Signature in Systemic Sclerosis Patients
Led by Hôpital Européen Marseille · Updated on 2025-09-25
60
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Today, the study of gut microbiota has taken a prominent place in several fields of medical research. Numerous experimental data in humans and animals suggest that an imbalance in the composition of the microbiota could contribute to the pathophysiology of systemic autoimmune diseases such as Systemic Sclerosis (SCS). A future exploration of the microbiota, a source of diagnostic and/or prognostic biomarkers, may be very useful for tomorrow's medicine by proposing therapeutic interventions based on the correction of possible imbalances in the intestinal flora. Studies of the human gut microbiota in patients with ScS are limited to low-impact investigations, due to the lack of data on the clinical and biological characterization of the patients studied, and to the absence of longitudinal studies in the same patient. For this reason, we are interested in exploring the intestinal microbiota of ScS patients in a comprehensive and longitudinal way.
CONDITIONS
Official Title
Longitudinal Characterization of Microbial Signature in Systemic Sclerosis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with Systemic Sclerosis according to ACR criteria
- Patients over 18 years old
- Patients who have signed consent to participate
- Control subjects without Systemic Sclerosis or any chronic disease
- Control subjects over 18 years old
- Control subjects who have signed consent to participate
You will not qualify if you...
- Persons with severe anemia (hemoglobin less than 7 g/dL)
- Persons unable to read French
- Control subjects with digestive symptoms or on long-term treatment for other diseases
- Persons treated with antibiotics, probiotics, prebiotics, or treatments disrupting gut microbiota within two months before stool sampling
- Pregnant women, women in labor, and breastfeeding mothers
- Persons deprived of liberty by judicial or administrative decision
- Persons under psychiatric follow-up
- Minors
- Persons under legal protection measures or unable to give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Européen Marseille
Marseille, France, 13003
Actively Recruiting
Research Team
E
Eya TOUMI, PhD student
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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