Actively Recruiting
Retrospective and Prospective Longitudinal Observational Study on Invasive Fungal Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Led by Peking University People's Hospital · Updated on 2026-05-06
6000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
P
Peking University People's Hospital
Lead Sponsor
F
First Affiliated Hospital of Guangxi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Invasive fungal disease (IFD) is a serious complication that can occur after allogeneic hematopoietic stem cell transplantation (HSCT), with a high rate of occurrence and mortality. This research aims to study the changing patterns of fungal infections and their clinical features following HSCT. It focuses on understanding the diagnosis, treatment, and outcomes of IFD patients, addressing the need for updated information due to evolving transplantation methods, new antifungal drugs, and improved diagnostic techniques. The study is designed as a combined retrospective and prospective longitudinal observational cohort. It includes three groups: patients treated before the study began contributing to the retrospective cohort, patients treated after the study starts joining the prospective cohort, and those with treatment spanning both periods forming an ambispective cohort. This approach allows researchers to collect and analyze comprehensive data on IFD cases over time from multiple centers. Participants will be observed through their medical records and follow-up visits as researchers collect information on their diagnosis, treatment, and health outcomes. The main measure is overall survival after HSCT, tracked for up to five years. Secondary measures include response rates to treatment, incidence of fungal infections, post-transplant complications, treatment-related side effects, and hospital stay length. This study will provide valuable evidence to improve diagnosis and care for patients facing IFD after HSCT.
CONDITIONS
Brief Title
Longitudinal Cohort Study on Invasive Fungal Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at Peking University People's Hospital or assisting centers since January 1, 2014
You will not qualify if you...
- Patients with severe mental disorders that make follow-up information unavailable
- Patients considered unsuitable for the study by the researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years after transplantation
Participants who underwent allogeneic hematopoietic stem cell transplantation are observed over time to monitor the occurrence of invasive fungal disease and other health outcomes.
Periodic visits as per routine clinical follow-up
Trial Site Locations
Total: 1 location
1
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
Research Team
J
Jin Wu, MD
F
Fanhao Nie
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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