Actively Recruiting
Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children
Led by Centre Hospitalier Universitaire de Saint Etienne · Updated on 2024-05-03
60
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. Many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting TNFα (Tumor Necrosis Factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation. While the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, the effect of major inflammation on the balance of the autonomic nervous system is more difficult to understand. The inflammatory reflex could be overwhelmed and the regulatory centers of the brainstem dysregulated during situations of extreme inflammation.
CONDITIONS
Official Title
Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized in a pediatric intensive care unit
- Meets sepsis criteria
- Covered by a social security scheme
- Parent or guardian has received study information and signed consent form
- For control group: Covered by a social security scheme
- For control group: Parent or guardian has received study information and signed consent form
You will not qualify if you...
- Parent or guardian does not speak French
- Has chronic or acute condition affecting autonomic balance (e.g., congenital heart disease, encephalopathy, neuropathy, acute pain)
- Received general anesthesia less than 48 hours ago (cases group) or less than 1 month ago (control group)
- Taking treatments that affect the autonomic nervous system (e.g., beta-blockers) or inflammation (NSAIDs, corticosteroids)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chu de Saint-Etienne
Saint-Etienne, France, 42055
Actively Recruiting
Research Team
H
HUGUES PATURAL, MD-PHD
CONTACT
M
MARINE DUBOIS, Resident
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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