Actively Recruiting
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Led by Patrick Lao · Updated on 2025-07-03
100
Participants Needed
1
Research Sites
288 weeks
Total Duration
On this page
Sponsors
P
Patrick Lao
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease and/or other related dementias to participate. This includes patients with: * Mild Cognitive Impairment * Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties * Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties * Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties * The investigators are also enrolling older adults with normal visual, language, and memory function.
CONDITIONS
Official Title
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 and over at time of screening
- No cognitive impairment or diagnosis of amnestic Alzheimer's disease, posterior cortical atrophy, or logopenic variant primary progressive aphasia confirmed by history, exam, neuropsychological testing, MRI, and consensus
- Clinical Dementia Rating scale score of 0.5 or 1 for patients; score of 0 for controls
- Able to provide informed consent or have a surrogate decision maker
- Written and oral fluency in English or Spanish
- Able to participate in all scheduled evaluations and complete all required tests and procedures
- Likely to comply with study protocol and complete the study, as judged by the principal investigator
You will not qualify if you...
- Past or present brain disorder other than Alzheimer's disease, including cortical infarct on MRI
- Serious medical conditions that make study procedures unsafe, such as uncontrolled epilepsy or multiple serious injuries
- Contraindication to MRI scanning
- Conditions preventing entry into scanners, like morbid obesity or claustrophobia
- Exposure to research-related radiation in the past year exceeding allowable limits when combined with this study
- Medication exclusions determined by the principal investigator in consultation with the medical liaison
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
A
Anna Smith
CONTACT
D
Diana S. Guzman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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