Actively Recruiting
Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Led by University of Zurich · Updated on 2020-12-29
400
Participants Needed
1
Research Sites
356 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary study objective: • Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort. Secondary study objectives: * Longitudinal observation of hemodynamic patterns versus structural brain tissue changes in neurosurgical patients. * Changes in blood flow patterns and structural brain tissue after neurosurgical interventions as compared to a healthy cohort. * Determining hemodynamic imaging patterns that can be tested as novel imaging markers.
CONDITIONS
Official Title
Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects over 18 years of age
- Written informed consent after receiving study information
- For non-German speakers, presence of a translator with sufficient German language skills
- Patients with neurosurgical diseases that may affect brain blood flow, including cerebrovascular disease, brain tumors, or normal pressure hydrocephalus
- Healthy subjects over 18 years of age with informed consent and translator if needed
You will not qualify if you...
- Unwilling or unable to cooperate with breathing maneuvers
- Respiratory or cardiac issues preventing breathing through a mask
- Medical contraindications to controlled high or low carbon dioxide levels (such as increased intracerebral pressure, metabolic acidosis or alkalosis)
- Standard MRI scanning contraindications
- Pregnancy
- Multiple intracranial diseases
- Intracranial hemorrhage within the last 3 months
- Symptomatic increased intracranial pressure
- For healthy subjects, history or current neurological diseases or deficits
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Zurich
Zurich, Switzerland, 8032
Actively Recruiting
Research Team
J
Jorn Fierstra, MD, PhD
CONTACT
L
Luca Regli, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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