Comparing Two Intermittent Fasting Methods and Weight-Loss Counseling in Obese Adults Aged 18 to 50

What this Trial Is About

Researchers are studying the effects of two different intermittent fasting methods compared to a control group on the health of obese adults. This randomized clinical trial focuses on adults aged 18 to 50 with obesity, aiming to understand how different fasting schedules may impact weight and metabolic health. The study also explores new ways to monitor progress during intermittent fasting, which has grown popular as a dietary approach to manage weight and improve health markers. Participants are divided into three groups one follows a modified alternate day fasting mADF protocol where they eat freely every other day and consume a very low carbohydrate snack only in the evening on fasting days another group practices time-restricted eating TRE, limiting food intake to two main meals between 1200 and 2000 daily and fasting outside these hours the third group receives general weight-loss counseling without food timing restrictions. The study will last 8 weeks, comparing these approaches side-by-side. During the study, participants will be regularly assessed for changes in fat volume, fat distribution, leptin concentration, insulin sensitivity, fasting lipids, inflammatory markers, and free triiodothyronine levels. These measurements help track the effects of the fasting protocols on body composition and metabolic health. The trial includes detailed monitoring of individual progress and adherence, with all groups receiving follow-up over the 8-week period to evaluate outcomes and safety.

Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults