Actively Recruiting
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Led by Stanford University · Updated on 2024-12-04
110
Participants Needed
1
Research Sites
412 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clinical indices with cellular changes.
CONDITIONS
Official Title
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35-65
- Body mass index (BMI) between 25 and 35 kg/m2
- Stable body weight
- Nondiabetic
You will not qualify if you...
- Diagnosis of diabetes
- Major organ disease
- History of liposuction or bariatric surgery
- Active eating or psychiatric disorder
- Pregnancy or lactation
- Heavy alcohol use
- Recent change in weight within the past 12 weeks
- Use of weight loss medication, statins, or oral steroids
- Hematocrit less than 33%
- Fasting glucose 126 mg/dL or higher
- Blood pressure higher than 160/100 mmHg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
E
Ekrem M Ayhan, BS
CONTACT
D
Dalia Perelman, MS, RD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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