Actively Recruiting
Study of Neurocognitive and Psychosocial Changes in Advanced Cancer Survivors Treated with Immunotherapy and Testing a New Integrative Cognitive Therapy Program
Led by Universitair Ziekenhuis Brussel · Updated on 2025-01-20
100
Participants Needed
2
Research Sites
369 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying long-term survivors of advanced cancer who have been treated with immunotherapy to understand their psychosocial and neurocognitive challenges. This research also aims to evaluate the effectiveness of an Integrative Neuro-Cognitive Remediation Therapy INCRT program designed to address emotional complaints, fatigue, fear of recurrence, neurocognitive functioning, and quality of life. The study includes three groups advanced cancer survivors treated with immunotherapy, cancer survivors treated with other therapies who have cognitive complaints, and survivors of central nervous system tumors without active disease but with cognitive issues. Participants in the study either undergo regular assessments or participate in the INCRT program. This 12-week behavioral program includes personalized computerized cognitive training, neurocognitive strategy training, and group sessions involving adapted physiotherapy, mindfulness, Acceptance and Commitment Therapy, cognitive behavioral therapy, and information on cognition, fatigue, nutrition, and physical exercise. Assessments occur at baseline, after completion of the program, and six months later to evaluate the therapys impact. Participants will complete interviews, questionnaires, and computerized neuropsychological tests to measure cognitive function, emotional distress, fatigue, fear of cancer recurrence, and health-related quality of life. These assessments are conducted at the start, six months, and one year later for the non-intervention group, and additionally before and after the INCRT program for those in the therapy group. Researchers will monitor these outcomes longitudinally for up to three years to understand long-term effects and therapy benefits.
CONDITIONS
Brief Title
Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Survivors Treated With Immunotherapy and the Efficacy of Integrative Neurocognitive Remediation Therapy
Research Team
N
Nathalie Vanlaer, MSc
A
Anne Rogiers, MD, PhD
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