A Study of Mild, Moderate and Severe Asthma Characterising Phenotypes and Endotypes and Their Long-Term Associations with Exacerbations and Disease Progression

What this Trial Is About

Researchers are studying how asthma varies among adults aged 18 and older, aiming to understand different asthma types and monitor changes over time. The study focuses on causes and triggers of asthma flare-ups, symptoms, airway inflammation, and how these factors influence respiratory health. This long-term observational study will help improve knowledge of asthma progression and outcomes by gathering detailed information from patients with mild to severe asthma. Participants will attend an initial screening visit to confirm eligibility and assess their asthma. This is followed by about five annual clinic visits and periodic phone follow-ups. Between annual visits, participants will perform self-assessments at home every six months and when experiencing cold-like symptoms. At home, participants will collect nasal and throat swabs and complete symptom, medication, and lung function diaries. The study may also include optional sub-studies involving additional tests and challenges. During the clinic visits, researchers will perform assessments such as spirometry, lung function tests, blood and respiratory sample collection, allergy skin prick tests, and questionnaires about asthma control and quality of life. Participants will be monitored for any side effects from tests like the methacholine challenge. Data collected will measure asthma exacerbation frequency and severity, lung function changes, inflammation markers, and symptom control over at least five years. Participants may withdraw at any time, and abnormal findings will be shared with them and their healthcare providers.

Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe Asthma