Actively Recruiting
A Longitudinal Photo-Narrative Exploration of Hope During Phase 1/2 Clinical Trials For Pediatric Cancer
Led by St. Jude Children's Research Hospital · Updated on 2026-04-28
100
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
Sponsors
S
St. Jude Children's Research Hospital
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to find better ways to help support families in their hopes during cancer treatment. Primary Objective * To characterize themes related to how patients and parents/caregivers narrate their experience of 'hope' when receiving cancer therapy on a phase 1/2 clinical trial, with a focus on whether, why, when, and how patients' and caregivers' hopes adapt to changing circumstances. * To engage patients, caregivers, and clinicians in focus groups to identify strengths, weaknesses, opportunities, and threats to hope during phase 1/2 clinical trial participation and facilitate the co-design of a stakeholder-driven supportive intervention related to hope based on focus group recommendations. Secondary Objective * To describe health care provider perspectives on patient and family hope and goal-care concordance in the context of phase 1/2 clinical trials.
CONDITIONS
Official Title
A Longitudinal Photo-Narrative Exploration of Hope During Phase 1/2 Clinical Trials For Pediatric Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient participants must be 12 to 25 years of age.
- Patient must have a primary cancer diagnosis that is relapsed, refractory, or without curative standard-of-care options.
- 'Relapsed' disease means recurrence after prior response to therapy.
- 'Refractory' disease means failure to achieve remission with standard upfront therapy.
- Diagnoses without curative options have no evidence-based curative regimens or only palliative intent.
- Patient must be enrolled or planning to enroll in a phase 1 or phase 2 trial for cancer therapy.
- Caregiver participants must be parent or primary caregiver to a child with relapsed, refractory, or incurable cancer.
- Caregivers must be enrolled or planning to enroll on a phase 1 or phase 2 cancer therapy trial.
- Caregivers must be 18 years or older or legally emancipated.
- Medical clinician participants must provide direct care to patient or child of caregiver participant.
- Psychosocial clinicians must provide direct or consultative care to relevant patients or families.
You will not qualify if you...
- Individuals who do not meet inclusion criteria.
- Those who decline, refuse, or are unwilling to participate.
- Minors without a legal guardian available or willing to provide consent.
- Persons lacking cognitive, communicative, or physical ability to participate meaningfully in photo-narrative interviews, including those with profound neurocognitive impairment or non-responsiveness.
AI-Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
A
Alexandra Superdock, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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