Actively Recruiting
Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
Led by University of Illinois at Chicago · Updated on 2024-09-19
250
Participants Needed
8
Research Sites
198 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Chicago
Lead Sponsor
U
University of California, San Francisco
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. The research aims are: 1. To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. 2. Identify plasma and imaging biomarkers sensitive to exacerbation of clinical symptoms including seizures, headaches, or stroke-like episodes. 3. For enrolled patients who present with severe neurological symptoms screen blood samples for inflammatory changes. The target enrollment for this study is about 250 individuals diagnosed with Sturge-Weber Syndrome. The goal of this study is to understand more about Sturge-Weber Syndrome, the possible treatments for this disease, and identify targets for clinical trials. Those participating in the database will be asked to consent to blood draws.
CONDITIONS
Official Title
Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with MRI-documented unilateral or bilateral leptomeningeal angiomas with or without neurological symptoms including seizures, headaches, and stroke-like episodes
- Patients of any age
- Availability of longitudinal clinical and imaging data from all patient EHR records
- Consent to being followed prospectively throughout the course of the study
- Willing to provide blood samples
- Severe seizures, headaches, or stroke-like episodes to trigger entry into Aim 1B
You will not qualify if you...
- Persons without physician diagnosed Sturge-Weber Syndrome
- Persons unwilling to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
University of Illinois At Chicago
Chicago, Illinois, United States, 60607
Actively Recruiting
3
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21213
Actively Recruiting
4
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
5
Wayne State University
Detroit, Michigan, United States, 48202
Actively Recruiting
6
University of New Mexico
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
7
Cincinnati Children's Hospital
Cincinnati, Ohio, United States, 45229
Actively Recruiting
8
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
Research Team
J
Jeffrey Loeb, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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