Actively Recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
Led by McMaster University · Updated on 2024-08-12
15
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate whether the gut bacteria in IBD patients cause ongoing abdominal pain, even when the disease is calm. Many inflammatory bowel disease (IBD) patients have this pain, regardless of whether their disease is active or not. This might be linked to an imbalance in gut bacteria. Certain IBD patients with persistent abdominal pain experience increased sensitivity in their gut due to bacteria producing LPC and LPA. Our goal is to explore the connection between bacterial LPC/LPA levels and symptoms in IBD patients with long-lasting abdominal pain. Additionally, we aim to pinpoint the specific bacteria responsible for producing LPC/LPA, which in turn causes chronic abdominal pain in these patients.
CONDITIONS
Official Title
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- Diagnosis of Crohn's disease with a history of moderate or severe chronic abdominal pain that persists during remission or mild inflammation
- Diagnosis of ulcerative colitis with a history of moderate or severe chronic abdominal pain that persists during remission or mild inflammation
- Remission defined as absence of overt inflammation on CT or MRI and fecal calprotectin less than 200 bcg/g of stool
- Mild inflammation defined by colonoscopy scores (Simple Endoscopic Score for Crohn's Disease: 0-10 or Endoscopic Mayo score: 0-1)
You will not qualify if you...
- Current use of acid anti-secretory and antacid medications
- Current or recent (within 8 weeks) use of antibiotics, antibacterial agents, or probiotics
- Current pain treatment with opioids or NSAIDs (acetaminophen allowed)
- Alcohol or drug abuse
- Presence of systemic disease or laboratory abnormalities that pose risk or interfere with data collection
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
McMaster University
Hamilton, Ontario, Canada, L8S 4L8
Actively Recruiting
Research Team
G
Gaston H Rueda, MD
CONTACT
A
Andrea Nardelli, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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