Actively Recruiting
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-07
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some individuals have a hereditary form of HES known as familial eosinophilia (FE). More research on the causation and mechanisms of HES is needed in order to design more effective and less toxic therapies. This study will investigate FE and its genetic causes, damage mechanisms, and disease markers (such as blood test abnormalities). It will enroll approximately 50 individuals (both adults and children) from a previously studied family with FE. This is a long-term study of indefinite duration. Participants will undergo yearly clinical examinations including medical history, physical examination, bloodwork, EKG, echocardiogram, and pulmonary function tests, with additional or more frequent examinations and tests as required. In addition, participants will donate blood and tissue for research purposes. Both adult and child participants will donate blood. At the initial evaluation, adult participants will donate bone marrow. During the study, some adult participants will also undergo a limited number of leukaopheresis sessions, in which blood is donated from one arm, the blood is separated into red blood cells and other components, and the red blood cells are returned into the donor's other arm.
CONDITIONS
Official Title
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to comply with all study procedures and available for the study duration
- Male or female aged 1 to 100 years
- Genetically related member of a previously identified family with familial hypereosinophilia (FE)
- Able to understand and willing to sign a written informed consent document
You will not qualify if you...
- Any condition that the investigator believes puts the subject at unacceptable risk for participation
- Pregnancy in family members who do not have eosinophilia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
T
Thomas W Brown, R.N.
CONTACT
A
Amy D Klion, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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