Actively Recruiting
Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-03
100
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
I
Institut National de la Santé Et de la Recherche Médicale, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium. This approach is feasible on small fragments of villi and offers for the first time the possibility to consider the characterization of gene expression within the structural unit of the human placenta during pregnancy (at the 1st trimester and childbirth)
CONDITIONS
Official Title
Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 50
- Progressive monofoetal pregnancy between 11 and 15 weeks of amenorrhea
- Patient with prenatal medical indication and requesting chorionic villus biopsy with cytogenetic analysis or molecular genetics
- Patient scheduled for delivery at Port-Royal Maternity Hospital
You will not qualify if you...
- Minor patient
- Multiple pregnancy
- Patient's objection
- Without health insurance
- Patient under guardianship or curatorship
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Maternité Port-Royal, Cochin hospital
Paris, IDF, France, 75014
Actively Recruiting
Research Team
V
Vassilis TSATSARIS, MD PHD
CONTACT
M
Marie BENHAMMANI-GODARD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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