Actively Recruiting
Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging
Led by Dr. Grace Parraga · Updated on 2024-06-13
200
Participants Needed
1
Research Sites
822 weeks
Total Duration
On this page
Sponsors
D
Dr. Grace Parraga
Lead Sponsor
L
London Health Sciences Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
Subjects male and female aged 50-85 with a clinical diagnosis of chronic obstructive pulmonary disease (COPD) or Bronchiectasis, or those with ≥ 10 pack/years smoking history will be imaged with CT and MRI for the development of tools to quantify and validate longitudinal in vivo magnetic resonance imaging phenotypes of COPD and Bronchiectasis.
CONDITIONS
Official Title
Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 50 to 85 years
- Clinical diagnosis of COPD or Bronchiectasis or smoking history of more than 10 pack-years
- Understands study procedures and willing to participate, indicated by signed informed consent
- Able to hold breath for 16 seconds
- Judged to be in stable health based on medical history
- Ambulatory and able to perform the six-minute walk test
- Able to perform reproducible pulmonary function testing with consistent spirometry results
- FEV1 greater than 25% predicted
- FVC greater than 25% predicted and greater than 0.5 liters
You will not qualify if you...
- Mentally or legally incapacitated, unable to provide informed consent, or cannot understand written materials
- Daytime resting oxygen saturation less than 90% while lying down
- Unable to perform spirometry or plethysmography tests
- Pregnant
- Physical or psychological conditions preventing MRI, including severe claustrophobia
- Implanted devices or metal in body incompatible with MRI, such as pacemakers, neurostimulators, insulin pumps, aneurysm clips, surgical staples, or metallic foreign bodies
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, Canada, N6A 5B7
Actively Recruiting
Research Team
G
Grace E Parraga, PhD
CONTACT
A
Angela P Wilson, RRT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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