Actively Recruiting
Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
Led by Western University, Canada · Updated on 2025-08-15
200
Participants Needed
1
Research Sites
443 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
CONDITIONS
Official Title
Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient understands study procedures and agrees to participate by signing consent
- Provides written informed consent before any study procedures
- Male or female aged 18 to 85 years
- Current or former cannabis smoker, medicinal or recreational, with or without tobacco use
- Able to perform reproducible pulmonary function tests with consistent forced expiratory volume
- Able to hold breath for 16 seconds
- Forced expiratory volume in 1 second (FEV1) greater than 25% predicted
- Forced vital capacity (FVC) greater than 25% predicted and more than 0.5 liters
You will not qualify if you...
- Mentally or legally incapacitated, unable to give informed consent, or cannot read/understand written material
- Medically unstable as judged by the principal investigator
- Daytime room air oxygen saturation less than 90% while lying down
- Unable to perform spirometry or plethysmography tests
- Pregnant at the time of enrollment
- Physical or psychological conditions preventing MRI, such as severe claustrophobia
- Has implanted mechanical, electrical, or magnetic devices or metal in the body that cannot be removed, including pacemakers, neurostimulators, insulin pumps, aneurysm clips, or surgical staples, at MRI technologist's discretion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, Canada, N6A 5B7
Actively Recruiting
Research Team
G
Grace E Parraga, PhD
CONTACT
A
Angela P Wilson, RRT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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