Actively Recruiting
Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-10-24
120
Participants Needed
1
Research Sites
361 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy.
CONDITIONS
Official Title
Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 18 years of age or older
- Planned treatment with commercial CD19-specific CAR T cells (axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, or brexacabtagene autoleucel) for lymphoma
- Patients must have adequate end organ function for CAR T cell therapy
- Eastern Cooperative Group (ECOG) performance status of 0 to 2
- Meet cardiac, pulmonary, hematologic, hepatic, and renal requirements for CAR T therapy as described in corresponding product package insert
- No evidence of central nervous system disease at study entry
- Fluent and able to communicate well enough in English to complete the study assessments and provide informed consent, in the judgment of the consenting professional
- Patients who report that English is not their primary language must speak English "very well" according to the US Census English proficiency question
You will not qualify if you...
- Signs and/or symptoms of central nervous system cancer (e.g., metastases, leptomeningeal disease) at enrollment or during the study
- Current diagnosis of major Axis I psychiatric disorder, major depression, bipolar disorder, or schizophrenia
- History of neurodegenerative disease or traumatic brain injury with loss of consciousness longer than 60 minutes
- History of epilepsy
- Current ongoing substance abuse or history of substance abuse
- Visual or auditory impairment that would prevent completion of assessments
- Contraindications to MRI examinations such as ferromagnetic material or implants, pacemakers or defibrillators, stents, or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
B
Bianca Santomasso, MD, PhD
CONTACT
D
Denise Correa, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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