Study of Single-Dose Losartan 50mg Effects on Emotional Learning and Cognitive Flexibility in Healthy Adults Aged 18 to 50

What this Trial Is About

Researchers are investigating how a single dose of losartan 50 mg affects emotional processing in healthy adults aged 18 to 50 years. This early-phase study explores the role of the renin-angiotensin system, which is involved in blood pressure regulation and is also present in brain areas linked to anxiety and depression. The study aims to understand how this system impacts cognitive functions related to emotional disorders and to identify potential overlaps with treatments for these conditions. Participants will be randomly assigned to receive either a single oral dose of losartan potassium 50 mg or a matching placebo capsule. This double-blind, triple-masked study includes 60 healthy volunteers. The effects on emotional learning and cognitive flexibility will be assessed about one hour after taking the capsule. The study compares the impact of losartan versus placebo on several cognitive tasks related to emotional processing. During the study, participants will complete various assessments focused on reinforcement learning, cognitive flexibility, the AAT effect score, and motivational effort in a specific task. These evaluations will occur approximately one hour after treatment intake. The researchers will monitor cognitive responses and emotional processing to understand losartans potential influence. The entire participation is designed for healthy adults with no major psychiatric or neurological conditions and includes screening for eligibility and informed consent.

Losartan and Emotional Learning