Actively Recruiting
Losartan and Emotional Learning
Led by University of Oxford · Updated on 2024-10-04
60
Participants Needed
1
Research Sites
45 weeks
Total Duration
On this page
Sponsors
U
University of Oxford
Lead Sponsor
N
National Institute for Health Research, United Kingdom
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
CONDITIONS
Official Title
Losartan and Emotional Learning
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide informed consent
- Aged 18-50 years
- Score of or below 45 on the Dimensional Anhedonia Rating Scale (DARS; Rizvi et al., 2015)
- Sufficient written and spoken English skills to understand what the study involves, and to complete the questionnaires
- Non- or light-smoker (5 cigarettes a day)
You will not qualify if you...
- Past or present DSM-5 axis-I diagnosis (based on SCID results at screening) other than anxiety disorder, dysthymia or unipolar depression
- First-degree family member with severe psychiatric illness
- CNS-medication last 6 weeks (including as part of another study)
- Current blood pressure or other heart medication (especially aliskiren or beta blockers)
- Diagnosis of intravascular fluid depletion or dehydration
- History of angioedema
- Impaired kidney function (based on self-report)
- Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below 90/50 mmHg)
- Lifetime history of epilepsy or other neurological disease (e.g. autism, ADHD)
- Lifetime history of systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which may put the participant at risk or affect study results
- Significant loss of hearing that is not corrected with a hearing device
- Women who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Warneford Hospital, University of Oxford
Oxford, Oxfordshire, United Kingdom, OX37JX
Actively Recruiting
Research Team
A
Andrea Reinecke, PhD
CONTACT
S
Sanika Kulkarni, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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