Actively Recruiting
Losartan and Emotional Processing in Young People
Led by University of Oxford · Updated on 2025-06-15
60
Participants Needed
1
Research Sites
94 weeks
Total Duration
On this page
Sponsors
U
University of Oxford
Lead Sponsor
N
National Institute for Health Research, United Kingdom
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.
CONDITIONS
Official Title
Losartan and Emotional Processing in Young People
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent (for ages 16-17: assent plus parental or guardian consent)
- Non-smoker or light smoker (fewer than 5 cigarettes daily)
- Able to attend study visits in Oxford with reasonable travel costs
- Willing and able to provide general practitioner contact details
You will not qualify if you...
- Any past or current DSM-5 axis-I psychiatric diagnosis, especially severe illness or substance dependence
- First-degree relative with severe psychiatric illness
- Use of central nervous system medication in the last 6 weeks
- Current use of blood pressure or heart medication, including aliskiren or beta blockers
- Diagnosis of dehydration or fluid depletion
- Kidney impairment (eGFR below 75 ml/min/1.73 m2)
- Significant high potassium levels (hyperkalaemia)
- Very low blood pressure (repeated readings below 90/50 mmHg)
- Body weight below 35 kg
- History of epilepsy or neurological disorders such as ADHD or autism
- History of angioedema, renal artery stenosis, heart valve disease, or recurrent orthostatic hypotension
- History of serious infections or major liver, heart, lung, kidney, metabolic, endocrine, or brain disorders that could affect safety or study results
- Significant hearing loss not corrected by a hearing device
- Insufficient English language skills
- Women who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Warneford Hospital, University of Oxford
Oxford, Oxfordshire, United Kingdom, OX37JX
Actively Recruiting
Research Team
A
Andrea Reinecke, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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