Actively Recruiting
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Led by Brigham and Women's Hospital · Updated on 2026-01-20
90
Participants Needed
3
Research Sites
208 weeks
Total Duration
On this page
Sponsors
B
Brigham and Women's Hospital
Lead Sponsor
U
University of Kentucky
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries involving disruption of 2 or more ligaments often coincide with injuries to arteries, nerves, tendons, menisci, and/or fractures and can be devastating events. MLKIs often require complex treatments nearly 2 in 5 patients suffer complications after surgery. Loss of knee range of motion is the most common complication and is associated with military separation. There are also long-term effects of motion loss, as the need for motion-restoring surgery after MLKI is associated with an increased risk of osteoarthritis within 5 years of surgery. A person's ability to perform both activities of daily living and higher demand physical activities is often impaired both in the short and long term. In fact, only 1 in 3 people return to high-level sport after MLKI. The purpose of this translational randomized clinical trial is to determine if a 30-day course of oral Losartan improves a person's ability to return to work or sport, range of motion and strength, and reduce knee inflammation in the first year after surgical treatment of an MLKI.
CONDITIONS
Official Title
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Multi-ligament knee injury defined as a complete grade III injury of 2 or more ligaments
- At least one ligament surgically reconstructed or repaired
- Willingness to comply with the study protocol and assessments
You will not qualify if you...
- Allergy to any active or inactive ingredient of losartan
- Pregnant, planning to become pregnant, or sexually active females not using effective contraception during the 30-day course of losartan
- Severe renal insufficiency, hepatic disease, hypotension, or hyperkalemia increasing risk of losartan side effects
- History of prior knee ligament surgery on the involved knee
- Undergoing staged surgical procedures for MLKI treatment
- Traumatic brain injury limiting ability to participate in postoperative care or rehabilitation
- Concomitant injury or surgery that prevents performing range of motion exercises (e.g., extensor mechanism rupture surgery, vascular graft surgery)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of Kentucky
Lexington, Kentucky, United States, 40536
Not Yet Recruiting
2
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20814
Not Yet Recruiting
3
Mass General Brigham
Foxborough, Massachusetts, United States, 02035
Actively Recruiting
Research Team
C
Cale Jacobs, PhD
CONTACT
M
Molly Zgoda
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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