Study of a Single 50mg Dose of Losartan on Social Processing in Healthy Adults Aged 18 to 50

What this Trial Is About

Researchers are examining how a single dose of losartan 50 mg compared to a placebo affects social processing in healthy adults aged 18 to 50 years. The study focuses on the brains renin-angiotensin system RAS, which may influence social functioning and emotional disorders. This early-phase randomized, double-blind trial seeks to understand losartans possible role in social cognitive processes. Participants receive either a single dose of losartan or a matching placebo capsule. After one hour, they complete various computer-based tasks designed to assess social behaviors and cognitive flexibility. These tasks include the Approach Avoidance Task, Interpretation Inflexibility Task, Social Learning Trust Game, and Cyberball to measure social approach, avoidance, learning, and reaction to social rejection. During the study visit, participants undergo assessments of social processing through these tasks about one hour after taking the capsule. Researchers measure outcomes such as social approach-avoidance responses and sensitivity to social rejection. The trial includes thorough screening for health and psychological conditions, and it monitors participant safety throughout. The total participation includes the screening and a single study visit lasting several hours.

Losartan and Social Processing