Actively Recruiting
Losartan and Social Processing
Led by University of Oxford · Updated on 2025-07-28
68
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
Sponsors
U
University of Oxford
Lead Sponsor
N
National Institute for Health Research, United Kingdom
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study explores the effects of single-dose losartan (50mg) versus placebo on social processing in healthy volunteers.
CONDITIONS
Official Title
Losartan and Social Processing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide informed consent
- Aged 18-50 years
- Sufficient written and spoken English skills to understand what the study involves, and to complete the questionnaires
- Non- or light-smoker (5 cigarettes a day, if vaping: less than 50 puffs)
- BMI between 18 - 30
You will not qualify if you...
- Current DSM-5 axis-I diagnosis or history of severe psychological disorder such as psychotic disorder, bipolar disorder, alcohol or substance abuse, or post-traumatic stress disorder
- First-degree family member with severe psychiatric illness including psychosis, bipolar disorder, unipolar psychotic depression
- CNS-medication use within last 6 weeks
- Current blood pressure or other heart medication including aliskiren and beta blockers
- Diagnosis of intravascular fluid depletion or dehydration
- History of angioedema
- Impaired kidney function
- Very low blood pressure (repeated measures below 90/50 mmHg)
- Lifetime history of epilepsy or other neurological disorder such as autism or ADHD
- Lifetime history of systemic infection or significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease that may pose risk or influence study results
- Significant hearing loss not corrected with a hearing device
- Women who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Warneford Hospital
Oxford, Oxfordshire, United Kingdom, OX37JX
Actively Recruiting
Research Team
A
Andrea Reinecke, PhD
CONTACT
D
Divya Prasad, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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