Actively Recruiting
Loss of Y Chromosome in Aortic Stenosis
Led by University of Virginia · Updated on 2024-09-19
200
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
CONDITIONS
Official Title
Loss of Y Chromosome in Aortic Stenosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male with aortic stenosis
- Aortic valve area less than 1.5 cm2
You will not qualify if you...
- Bicuspid aortic valve
- History of radiation to chest
- Inflammatory autoimmune or rheumatologic diseases linked to aortic stenosis
- Active cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
Research Team
J
Jonathan R Lindner, MD
CONTACT
B
Bethany Gholson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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