Actively Recruiting
Low-dose Buprenorphine Initiation for Opioid Use Disorder
Led by Montefiore Medical Center · Updated on 2025-09-17
70
Participants Needed
1
Research Sites
137 weeks
Total Duration
On this page
Sponsors
M
Montefiore Medical Center
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test whether low-dose buprenorphine initiation for treatment of opioid use disorder is safe and effective.
CONDITIONS
Official Title
Low-dose Buprenorphine Initiation for Opioid Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and be available for the study duration
- Any gender, aged 18 years or older
- Diagnosis of opioid use disorder based on DSM-5 criteria
- Ability to take sublingual medication
- Willingness to follow the assigned buprenorphine initiation regimen
- Fluency in English or Spanish
- For those who can become pregnant, agreement to use highly effective contraception during the study
You will not qualify if you...
- Use of FDA-approved medications for opioid use disorder treatment within 7 days before screening, including methadone, buprenorphine, or naltrexone
- Diagnosis of severe alcohol use disorder or severe benzodiazepine use disorder
- Severe untreated mental illness such as psychosis or suicidality
- Acute or chronic medical conditions that make participation medically unsafe
- Pregnancy or breastfeeding
- Known allergy to buprenorphine or naloxone
- Inability to consent due to cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
Research Team
B
Benjamin T Hayes, MD, MS, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here