Comparing Low Dose Dexmedetomidine and Normal Saline Infusions for Pain and Lung Function in Adults With Multiple Rib Fractures

What this Trial Is About

This research aims to compare the effects of low dose dexmedetomidine infusion with normal saline on diaphragmatic function, pain quality, and anti-inflammatory properties in patients who have multiple fractured ribs and are receiving conservative treatment. The study focuses on adults aged 18 to 65 years with three or more rib fractures caused by trauma. Participants will be randomly assigned to one of two groups one group will receive a low dose dexmedetomidine infusion of 0.2 micrograms per kilogram per hour intravenously for 5 days during their ICU stay, while the other group will receive a matching dose and duration of normal saline. Before starting the intervention, a thoracic epidural will be inserted. The treatment period lasts for 5 days. During the study, participants will undergo assessments including ultrasonographic evaluation of diaphragm function over 5 days and pain measurement using a visual analogue scale during the first 48 hours. Researchers will monitor diaphragmatic performance, pain levels, and inflammation. The study involves close monitoring during ICU admission and collects data to evaluate the treatments impact on respiratory muscle function and pain control.

Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs