Actively Recruiting
Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study
Led by Cambridge University Hospitals NHS Foundation Trust · Updated on 2024-06-10
60
Participants Needed
1
Research Sites
297 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The preceding IVORY trial (NCT04241601) has completed. As atherosclerosis and its complications are driven by inflammation the investigators hypothesise that treatment with low-dose IL2 may reduce adverse cardiovascular outcomes compared to placebo. In this follow-up study, the investigators aim to collect cardiovascular clinical outcome data for patients who completed the IVORY clinical trial and will look at major adverse cardiovascular events (MACE), defined as cardiovascular death, non-fatal myocardial infarction, resuscitated cardiac arrest, ischaemic stroke, or unplanned coronary revascularization. In addition, data on adverse events such as all cause death, haemorrhagic stroke, new atrial fibrillation, ventricular arrhythmias, hospitalisation due to cardiovascular causes (e.g. stable and unstable angina, TIAs, heart failure), amputations and revascularisation due to peripheral vascular disease.
CONDITIONS
Official Title
Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants who completed the full per-protocol treatment regime of low-dose IL2 or placebo having attended the final dosing visit in the IVORY trial
- IVORY patients who previously consented to have their medical records inspected and who have already passed away at the start of this follow-up study
You will not qualify if you...
- Patients who decline participation
- Patients who did not consent to being contacted about future research
- Patients who were withdrawn from the IVORY trial for any reason
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Addenbrooke's Hospital
Cambridge, Cambridgeshire, United Kingdom, CB20QQ
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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