Actively Recruiting
Led by University of Alberta · Updated on 2026-04-28
100
Participants Needed
9
Research Sites
26 weeks
Total Duration
Researchers are evaluating the effects of different dose-intensities of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI) who require dialysis in the intensive care unit. The study aims to determine whether a lower CRRT dose-intensity is as effective as the current standard dose, with the hope that a lower dose may improve kidney recovery, shorten dialysis duration, and reduce costs and nursing workload. This trial is a pilot randomized study designed to generate high-quality evidence to guide future clinical practice. Participants will be randomly assigned to one of two groups: the intervention group will receive a low dose-intensity CRRT of 10-15 mL/kg/hr, while the control group will receive the standard dose-intensity of 25-30 mL/kg/hr, as recommended by current guidelines. Treatments will be delivered continuously while patients require CRRT in the intensive care unit. The trial focuses on comparing these two dosing strategies during the CRRT period. During the study, researchers will monitor the delivered CRRT dose-intensity for about one month and assess feasibility measures such as consent rate, recruitment rate, and adherence to the assigned dose over 90 days. They will also evaluate patient outcomes related to CRRT duration and kidney recovery. Participants or their representatives will provide informed consent, and safety and compliance with the study protocol will be closely followed throughout the trial period.
CONDITIONS
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Until kidney recovery or liberation from CRRT
Participants receive continuous renal replacement therapy (CRRT) at either a low dose-intensity or standard dose-intensity while being critically ill with acute kidney injury.
Continuous therapy in the intensive care unit
Duration - Up to 90 days
Participants are monitored for up to 90 days to assess kidney recovery, duration of CRRT, and adherence to prescribed dose-intensity.
Follow-up assessments as per clinical care
Total: 9 locations
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
2
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
3
Grey Nuns Hospital
Edmonton, Alberta, Canada
Actively Recruiting
4
Sturgeon Community Hospital
St. Albert, Alberta, Canada, T8N 6C4
Actively Recruiting
5
Hamilton General Hospital
Hamilton, Ontario, Canada
Actively Recruiting
6
Sunnybrook Health Sciences Centre
North York, Ontario, Canada, M4N 3M5
Actively Recruiting
7
St Michael's Hospital
Toronto, Ontario, Canada
Actively Recruiting
8
Regina General Hospital/Saskatchewan Health Authority
Regina, Saskatchewan, Canada
Actively Recruiting
9
Guy's & St Thomas' Hospitals
London, United Kingdom, SE1 9RT
Actively Recruiting
S
Sean M Bagshaw, MD
E
Ellen Morrison, PhD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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William Beaubien-Souligny, Melissa Thompson Bastin, J Pedro Teixeira...
https://pubmed.ncbi.nlm.nih.gov/40779331