Actively Recruiting
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
Led by University of Alberta · Updated on 2026-04-28
100
Participants Needed
9
Research Sites
132 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An estimated 10-15% of critically ill patients with acute kidney failure in the intensive care unit receive acute dialysis therapy. The majority of these patients initially receive a continuous form of dialysis therapy call continuous renal replacement therapy (CRRT). Prior studies have suggested that higher CRRT dose-intensity improved health outcomes for these patients; however, this was not found in high-quality clinical trials. These more recent trials suggested a lower range of dose-intensity compared with the higher range as the new standard of care. This was incorporated into guidelines. To date, no clinical trials have evaluated this lower range and specifically, it is plausible that an even lower dose-intensity of CRRT may be well tolerated, safe, associated with similar outcomes and be more cost-effective. This is the objective of the WISDOM trial, to compare the guideline standard with lower dose-intensity among patients who are started on CRRT in the intensive care unit.
CONDITIONS
Official Title
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Weight 55 kg or more
- Plan to start CRRT or started CRRT within the last 24 hours for acute kidney injury
- Expected to survive and receive CRRT for at least 48 hours
- Able to provide informed consent or have an authorized representative provide consent
You will not qualify if you...
- Need for sustained higher dose-intensity CRRT as determined by treating clinicians
- End-stage kidney disease on maintenance dialysis
- Received any renal replacement therapy for acute kidney injury during current hospital stay
- Unable to follow study protocol requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
2
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
3
Grey Nuns Hospital
Edmonton, Alberta, Canada
Actively Recruiting
4
Sturgeon Community Hospital
St. Albert, Alberta, Canada, T8N 6C4
Actively Recruiting
5
Hamilton General Hospital
Hamilton, Ontario, Canada
Actively Recruiting
6
Sunnybrook Health Sciences Centre
North York, Ontario, Canada, M4N 3M5
Actively Recruiting
7
St Michael's Hospital
Toronto, Ontario, Canada
Actively Recruiting
8
Regina General Hospital/Saskatchewan Health Authority
Regina, Saskatchewan, Canada
Actively Recruiting
9
Guy's & St Thomas' Hospitals
London, United Kingdom, SE1 9RT
Actively Recruiting
Research Team
S
Sean M Bagshaw, MD
CONTACT
E
Ellen Morrison, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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