Actively Recruiting
Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer
Led by Sichuan University · Updated on 2026-01-02
30
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II study aims to evaluate the efficacy and safety of low-dose radiation + SBRT + Tislelizumab plus platinum-based chemotherapy as neoadjuvant therapy for stage II-III non-small cell lung cancer.
CONDITIONS
Official Title
Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years
- Untreated stage IIA to IIIB non-small cell lung cancer confirmed by cytology or histology
- Lung tumors assessed as resectable or potentially resectable by a team including a thoracic surgeon
- At least one measurable lesion on imaging by RECIST v1.1 criteria
- Ability to provide tumor tissue suitable for PD-L1 expression testing
You will not qualify if you...
- Small cell lung cancer or mixed small cell and non-small cell lung cancer
- Known EGFR-sensitive mutations or ALK gene fusion
- Previous treatment with anti-PD-1, anti-PD-L1, anti-PD-L2 drugs, or other T cell receptor-targeting therapies
- Known or suspected autoimmune disorders or immunodeficiency, except well-controlled hypothyroidism or type I diabetes
- Active infections requiring systemic treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
West China Hospital of Sichuan University
Chengdu, China, China, 610041
Actively Recruiting
Research Team
J
Jianxin Xue, MD. Phd
CONTACT
Y
You Lu, MD. PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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