Study of Low-Dose Radiotherapy to Treat Painful Bone Metastases in Multiple Myeloma Patients

What this Trial Is About

Researchers are evaluating low-dose radiotherapy to treat bone pain in patients with multiple myeloma that has spread to the bones. This Phase II trial aims to see if a lower dose radiation treatment can reduce pain as effectively as the current standard care, while potentially being more convenient and causing fewer short- or long-term side effects. The study also looks at quality of life and pain medication use after treatment. Participants receive low-dose radiation therapy of 2 Gy on two consecutive business days. If patients do not experience pain relief, they may receive additional radiotherapy four weeks later. After treatment, patients are followed up at 2, 4, and 8 weeks, and again at 6 months to monitor outcomes and any changes. During the study, patients will be assessed for pain relief using patient reports and questionnaires that measure quality of life. Researchers will also track pain medication use and monitor any side effects or disease progression. The main outcome is pain response up to six months after radiation therapy. The total participation duration includes treatment and follow-up visits over six months.

Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma