Actively Recruiting
Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
Led by University of Southern California · Updated on 2025-07-11
100
Participants Needed
9
Research Sites
417 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.
CONDITIONS
Official Title
Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic diagnosis of multiple myeloma
- Painful bone metastasis (index lesion) with radiographic confirmation
- Any number of prior chemotherapy or immunotherapy treatments allowed
- Changes to systemic therapy or bisphosphonate use allowed 4 weeks before and after radiation therapy with recording
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2
- Brief Pain Inventory (BPI) score of 2 or higher
- Ability to understand and willingness to sign written informed consent
You will not qualify if you...
- Prior radiation therapy or palliative surgery to the index lesion
- Pathologic fracture or impending fracture at the index lesion site or planned surgical fixation there
- Clinical or radiographic evidence of spinal cord or cauda equina compression from the index lesion
- Index lesions located at the skull base or orbital lesions
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
2
Los Angeles General Medical Center
Los Angeles, California, United States, 90033
Actively Recruiting
3
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
4
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
5
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
6
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
7
University of Minnesota - Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
8
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
9
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
C
Christine Duran
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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