Actively Recruiting
Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients
Led by Southwest Hospital, China · Updated on 2026-04-23
798
Participants Needed
49
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The DATE-AGING study is a prospective, multicenter, randomized controlled trial investigating low-dose tenecteplase in elderly patients with acute ischemic stroke. Its primary objective is to evaluate the safety and efficacy of low-dose tenecteplase in elderly patients within 4.5 hours of acute ischemic stroke onset.
CONDITIONS
Official Title
Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 70 years or older
- Diagnosis of ischemic stroke with measurable neurological deficit (NIHSS 1 to 25); if NIHSS less than 4, must have measurable motor power deficit of at least 1 in upper or lower limbs
- Stroke symptoms present for at least 30 minutes without significant improvement before randomization
- Able to start thrombolytic therapy within 4.5 hours of stroke onset
- Premorbid modified Rankin Scale score of 0 or 1
- Informed consent provided by patient or surrogate
You will not qualify if you...
- Imaging shows multi-lobar infarction affecting more than one-third of a cerebral hemisphere
- Acute bleeding disorders or allergy to tenecteplase, including:
- Known genetic bleeding predisposition or recent significant bleeding within 6 months
- Heparin use within 48 hours with prolonged aPTT
- Use of vitamin K antagonists or novel oral anticoagulants with abnormal coagulation tests
- Platelet count below 100 x 10^9/L
- History of central nervous system damage or surgery
- Recent traumatic heart massage or non-compressive blood vessel puncture within 10 days
- Known or suspected intracranial hemorrhage or subarachnoid hemorrhage
- Neoplasm with increased bleeding risk
- Recent ulcerative gastrointestinal disease, esophageal varices, arterial aneurysms, or vascular malformations
- Significant trauma or major surgery within the past 3 months
- Any disorder with a significant bleeding risk
- Presence of intracranial hemorrhage
- Blood glucose below 2.8 mmol/L or above 22.22 mmol/L
- Uncontrolled hypertension after treatment (systolic ≥180 mmHg or diastolic ≥100 mmHg)
- Seizure at stroke onset
- Concurrent malignancy or severe systemic disease with expected survival under 90 days
- Participation in other clinical trials within 3 months prior to screening
- Investigator judgment deeming unsuitability for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 49 locations
1
Southwest Hospital, Chongqing, China
Chongqing, Chongqing Municipality, China, 400038
Actively Recruiting
2
Anshan Changda Hospital
Anshan, China
Not Yet Recruiting
3
Anyang People's Hospital
Anyang, China
Actively Recruiting
4
Huaxian People's Hospital of Henan
Anyang, China
Actively Recruiting
5
Baoshan People's Hospital
Baoshan, China
Not Yet Recruiting
6
People's Hospital of Zhijin County
Bijie, China
Not Yet Recruiting
7
Bishan Hospital
Chongqing, China
Not Yet Recruiting
8
Chongqing Emergency Medical Center
Chongqing, China
Actively Recruiting
9
Chongqing University Fuling Hospital
Chongqing, China
Actively Recruiting
10
Chongqing University Jiangjin Hospital
Chongqing, China
Actively Recruiting
11
Chongqing University Three Gorges Hospital
Chongqing, China
Not Yet Recruiting
12
Dianjiang People's Hospital OF Chongqing
Chongqing, China
Not Yet Recruiting
13
People's Hospital Of Xiushan County
Chongqing, China
Not Yet Recruiting
14
The People's Hospital of Dazu Chongqing
Chongqing, China
Not Yet Recruiting
15
The People's Hospital of HeChuan, Chongqing
Chongqing, China
Actively Recruiting
16
The People's Hospital of Rongchang Chongqing
Chongqing, China
Actively Recruiting
17
The People's Hospital of Tongnan District Chongqing City
Chongqing, China
Actively Recruiting
18
The Seventh People's Hospital of Chongqing
Chongqing, China
Actively Recruiting
19
Tongliang Hospital
Chongqing, China
Actively Recruiting
20
Yunyang County People's Hospital
Chongqing, China
Actively Recruiting
21
Dali Bai Autonomous Prefecture People's Hospital
Dali, China
Not Yet Recruiting
22
Dazhou Central Hospital
Dazhou, China
Not Yet Recruiting
23
The People's Hospital of Zhongjiang
Deyang, China
Not Yet Recruiting
24
Guang an People's Hospital
Guang’an, China
Not Yet Recruiting
25
Guizhou Provincial People's Hospital
Guiyang, China
Not Yet Recruiting
26
The Second People's Hospital of Guiyang（Guiyang Jinyang Hospital）
Guiyang, China
Not Yet Recruiting
27
The First Affiliated Hospital of Harbin Medical University
Ha’erbin, China
Not Yet Recruiting
28
Xunxian People's Hospital
Hebi, China
Actively Recruiting
29
Heyuan People's Hospital
Heyuan, China
Not Yet Recruiting
30
Qichun People's Hosiptal
Huanggang, China
Actively Recruiting
31
The People's Hospital Of Jianyang City
Jianyang, China
Not Yet Recruiting
32
Laixi People's Hospital
Laixi, China
Not Yet Recruiting
33
Leshan Geriatric Specialized Hospital
Leshan, China
Actively Recruiting
34
People's Hospital of Leshan
Leshan, China
Not Yet Recruiting
35
Luoyang Mengjin People's Hospital
Luoyang, China
Actively Recruiting
36
Nanbu People's Hospital
Nanchong, China
Actively Recruiting
37
Puyang People's Hospital
Pujiang, China
Not Yet Recruiting
38
The People's Hospital of Nan Le Xian
Pujiang, China
Actively Recruiting
39
People's Hospital of Ningling County
Shangqiu, China
Actively Recruiting
40
The First People's Hospital of Shangqiu
Shangqiu, China
Actively Recruiting
41
The First People ' S Hospital of Shao Yang
Shaoyang, China
Actively Recruiting
42
The People's Hospital of Gaocheng
Shijiazhuang, China
Actively Recruiting
43
Wuhan Puren Hospital
Wuhan, China
Actively Recruiting
44
Xiangyang NO.1 People's Hospital
Xiangyang, China
Actively Recruiting
45
The second people's hospital of Yibin
Yibin, China
Actively Recruiting
46
Zhumadian Central Hospital
Zhumadian, China
Actively Recruiting
47
Zhuzhou Central Hospital
Zhuzhou, China
Not Yet Recruiting
48
Zigong Third People's Hospital
Zigong, China
Actively Recruiting
49
Ziyang Central Hospital
Ziyang, China
Not Yet Recruiting
Research Team
H
Hou Xianhua
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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