Actively Recruiting
Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy
Led by Kayseri City Hospital · Updated on 2026-04-27
70
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient. This single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study. The primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat. The secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.
CONDITIONS
Official Title
Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologists (ASA) physical status I-II
- Aged between 18 and 65 years
- Patients who provide written informed consent to participate in the study
You will not qualify if you...
- Recent history of upper respiratory tract infection
- Recent history of sore throat
- Chronic cough
- History of previous neck or tracheal surgery
- Predictors of difficult intubation
- History of difficult intubation
- Obesity (BMI > 35 kg/m8)
- Chronic respiratory diseases such as asthma or COPD
- Pregnancy
- Use of dexamethasone
- Hepatic impairment
- Allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide
- Known allergy to halogenated anesthetic agents
- History of malignant hyperthermia
- Mental disorders or inability to provide reliable assessment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kayseri City Hospital
Kayseri, Kocasinan, Turkey (Türkiye), 38080
Actively Recruiting
Research Team
E
Emine Sümeyye Akköze
CONTACT
Ş
Şaziye Burcu Tufaoğulları Erdoğan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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