Actively Recruiting
Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma
Led by Fondazione del Piemonte per l'Oncologia · Updated on 2026-03-20
30
Participants Needed
1
Research Sites
90 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.
CONDITIONS
Official Title
Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Age 18 years or older
- CT evidence of a lung nodule suspicious for lepidic-predominant lung adenocarcinoma (LPA) or lung biopsy confirming LPA
- Target lung nodule diameter of at least 10 mm
- ECOG performance status between 0 and 2
- Willingness and ability to follow a controlled ketogenic diet for 7 days
- Ability to comply with study procedures and visit schedule
You will not qualify if you...
- Unsuitable for prolonged imaging procedures
- Renal failure
- Type 1 diabetes mellitus
- Pancreatitis
- Severe dyslipidemia
- Other malignancies progressing or treated actively within the last 3 years
- Serious or unstable medical, psychiatric, or substance use disorders affecting participation
- Pregnancy or breastfeeding
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060
Candiolo, Torino (TO), Italy, 10060
Actively Recruiting
Research Team
A
Alessio Rizzo, MD
CONTACT
A
Annamaria Nuzzo, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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