Actively Recruiting
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
Led by Ali Rezai · Updated on 2025-11-24
15
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
CONDITIONS
Official Title
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and non-pregnant females aged 45 to 85 years
- Able and willing to give informed consent
- Must meet clinical criteria for mild cognitive impairment due to Alzheimer's disease
- If receiving acetylcholinesterase inhibitors and/or memantine, must be on a stable dose for at least 45 days
- Able to communicate sensations during the LIFU procedure
You will not qualify if you...
- Unable to undergo MRI due to implanted pacemakers, medication pumps, aneurysm clips, metallic prostheses, shrapnel, permanent make-up, small metal fragments in the eye, or claustrophobia
- More than 30% of the skull along the sonication path covered by scars, scalp disorders, scalp atrophy, or implanted objects
- History of seizure disorder
- Clinically significant chronic pulmonary disorders such as severe emphysema or pulmonary vasculitis
- Does not speak English
- Pregnant or planning to become pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rockefeller Neuroscience Institute at West Virginia University
Morgantown, West Virginia, United States, 26505
Actively Recruiting
Research Team
M
Marc Haut, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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