Actively Recruiting
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
Led by University of California, Los Angeles · Updated on 2026-04-16
144
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).
CONDITIONS
Official Title
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of amnestic Mild Cognitive Impairment or Mild Alzheimer's Disease
- Age between 50 and 90 years
- English-speaking
- Ability to provide informed consent
- Normal or corrected-to-normal hearing and vision
You will not qualify if you...
- Participation in another clinical trial
- Current use of immunotherapeutic medications for cognition (Aduhelm, Leqembi, Kisunla)
- Moderate to severe Alzheimer's Disease
- Unable to provide informed consent
- Weight over 275 pounds
- Pregnancy, suspected pregnancy, or trying to become pregnant
- Claustrophobia or difficulties during previous MRIs
- Presence of certain dental devices such as top permanent retainers, 5 or more non-removable gold teeth, metal braces, top spacers, or palate expanders
- Implanted devices like cardiac pacemakers, aneurysm clips, cochlear implants, defibrillators, electrodes or wires, magnetically-activated devices, spinal cord stimulators, infusion or insulin pumps, implanted drug infusion devices, or deep brain stimulation devices
- Non-removable hairpieces, hairpiece extensions, or piercings
- Facial tattoos or permanent makeup
- MR-incompatible metal implants or unknown MR compatibility
- Previous metallic foreign body injury without doctor's confirmation of full removal
- Diagnosis of neurological disorders such as Parkinson's disease, Lou Gehrig's disease (ALS), Multiple sclerosis, or Cerebral Palsy
- Diagnosis of genetic disorders like Cystic Fibrosis or Sickle Cell Disease
- Diagnosis of psychiatric disorders including Bipolar disorder or Psychosis
- Uncontrolled psychiatric illness within the last two months
- Severe lung, liver, heart, or kidney disease
- Thyroid disorder or recent change in thyroid medication dose within three months
- Cancer treatment involving chemotherapy or radiation to head and neck, or stage 4 metastatic cancer
- Autoimmune disorders or viral infections affecting cognition or memory
- Substance abuse history within the past year
- History of stroke except transient ischemic attack lasting less than one week
- History of two or more seizures or epilepsy unless seizures occurred prior to age 5 with fever
- History of brain tumor, aneurysm, hemorrhage, or subdural hematoma
- Head injury causing loss of consciousness over 30 minutes or cognitive issues over 18 months
- Uncontrolled high blood pressure or diabetes
- Heart attack within the last year
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UCLA Semel Institute for Neuroscience and Behavior
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
N
Natalie Rotstein
CONTACT
S
Sabrina Halavi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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