Actively Recruiting
Low-Intensity Mechanical Stimulation for Hematologic Malignancy Patients
Led by Roswell Park Cancer Institute · Updated on 2025-12-03
75
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial tests the effect of low-intensity mechanical stimulation (LIMS) vibration therapy in patients with hematologic malignancies. Patients with hematologic malignancies often undergo a blood and/or bone marrow transplant (hematopoietic cell transplantation \[HCT\]) or cellular therapy. The LIMS board delivers vibrations through the bones that may stimulate bone growth and may also increase muscle activity and strength and may also increase T-cell activation in patients planning to undergo cellular therapy. LIMS vibration therapy may stop or reverse BMD loss and/or improve the development of T-cells in the body in patients with hematologic malignancies who are undergoing or may plan to undergo HCT or cellular therapies.
CONDITIONS
Official Title
Low-Intensity Mechanical Stimulation for Hematologic Malignancy Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- COHORT I: Eligible for first autologous or allogeneic hematopoietic cell transplantation (HCT); patients with preexisting osteoporosis are allowed
- COHORT I: Scheduled to undergo autologous or allogeneic HCT
- COHORT I: At least 18 years old
- COHORT I: Able to understand and sign informed consent
- COHORT II: At least 18 years old
- COHORT II: Diagnosed with non-Hodgkin lymphoma (diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia); patients with preexisting osteoporosis are allowed
- COHORT II: Able to understand and sign informed consent
You will not qualify if you...
- COHORT I: Any prior allogeneic HCT
- COHORT I: Any prior autologous HCT if planning autologous HCT
- COHORT I: Pre-transplant weight 275 lbs or more
- COHORT I: Body mass index (BMI) less than 18 kg/m2
- COHORT I: Recipient of cord blood transplant
- COHORT I: Diagnosis of multiple myeloma or amyloidosis
- COHORT I: History of central nervous system hemorrhage within 60 days
- COHORT I: History of any aneurysm (cerebral, aortic, etc.)
- COHORT I: Recent pulmonary embolism or deep vein thrombosis
- COHORT I: Presence of a cardiac pacemaker
- COHORT I: Prior non-traumatic (spontaneous) fracture
- COHORT I: Total joint replacement
- COHORT I: History of kidney or gall stones within 2 years unless gall bladder removal was done
- COHORT I: Any prosthetic lower extremity or limb
- COHORT I: Pregnant or nursing female
- COHORT I: Unable or unwilling to follow protocol requirements
- COHORT I: Any condition making the patient unsuitable for study intervention
- COHORT II: Planned CAR T-cell therapy within 2 months
- COHORT II: Prior CAR T-cell therapy
- COHORT II: Active treatment within last 60 days
- COHORT II: Pre-transplant weight 275 lbs or more
- COHORT II: Body mass index (BMI) less than 18 kg/m2
- COHORT II: History of central nervous system hemorrhage within 60 days
- COHORT II: History of any aneurysm (cerebral, aortic, etc.)
- COHORT II: Recent pulmonary embolism or deep vein thrombosis
- COHORT II: Presence of a cardiac pacemaker
- COHORT II: Recent non-traumatic fracture within 60 days
- COHORT II: Recent surgery within 60 days
- COHORT II: Pregnant or nursing female
- COHORT II: Unable or unwilling to follow protocol requirements
- COHORT II: Any condition making the patient unsuitable for study intervention
AI-Screening
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Trial Site Locations
Total: 1 location
1
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States, 14263
Actively Recruiting
Research Team
M
Megan Herr, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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